[artículo] 
inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 417-422

Título :	Intravenous versus oral administration of amitriptyline in patients with major depression
Tipo de documento:	texto impreso
Autores:	Eberhard A. Deisenhammer, Autor ; Alexandra B. Whitworth, Autor ; Christian Geretsegger, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 417-422
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Amitriptilina, Antidepresivos tricíclicos, Trastorno depresivo, Interacciones con la drogas.
Resumen:	Antidepressants can be administered by different routes. Advantages for either the oral or the intravenous administration have been suggested from pharmacokinetic as well as from clinical points of view. Controlled comparison studies of the two routes do not provide unequivocal recommendations. In this investigation, amitriptyline was studied over a 4-week period consisting of a 2-week, double-blind/double-dummy phase with either oral (150 mg/day), high-dose intravenous (150 mg/day), or medium-dose intravenous (100 mg/day) treatment and a 2-week phase of open oral treatment in 80 patients with major depression.
Link:	./index.php?lvl=notice_display&id=31177

[artículo] Intravenous versus oral administration of amitriptyline in patients with major depression [texto impreso] / Eberhard A. Deisenhammer, Autor ; Alexandra B. Whitworth, Autor ; Christian Geretsegger, Autor . - 2023 . - pp. 417-422.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 417-422

Palabras clave:	Amitriptilina, Antidepresivos tricíclicos, Trastorno depresivo, Interacciones con la drogas.
Resumen:	Antidepressants can be administered by different routes. Advantages for either the oral or the intravenous administration have been suggested from pharmacokinetic as well as from clinical points of view. Controlled comparison studies of the two routes do not provide unequivocal recommendations. In this investigation, amitriptyline was studied over a 4-week period consisting of a 2-week, double-blind/double-dummy phase with either oral (150 mg/day), high-dose intravenous (150 mg/day), or medium-dose intravenous (100 mg/day) treatment and a 2-week phase of open oral treatment in 80 patients with major depression.
Link:	./index.php?lvl=notice_display&id=31177