[artículo] 
inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 428-434

Título :	Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes
Tipo de documento:	texto impreso
Autores:	Alex Hemeryck, Autor ; Cindy De Vriendt, Autor ; Frans M. Belpaire, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 428-434
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Antiarritmias, Desalquilación, Depresión, Hidroxilación, Técnicas In Vitro, Microsomas, Propafenona.
Resumen:	Propafenone is mainly metabolized by CYP2D6 to form 5-hydroxypropafenone (5-OHP) and to a minor extent by CYP1A2 and CYP3A4 to form N-depropylpropafenone (N-DPP). The in vitro inhibitory effect of selective serotonin reuptake inhibitors (SSRIs) on the formation of both metabolites was studied, using human liver microsomes.
Link:	./index.php?lvl=notice_display&id=31179

[artículo] Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes [texto impreso] / Alex Hemeryck, Autor ; Cindy De Vriendt, Autor ; Frans M. Belpaire, Autor . - 2023 . - pp. 428-434.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 428-434

Palabras clave:	Antiarritmias, Desalquilación, Depresión, Hidroxilación, Técnicas In Vitro, Microsomas, Propafenona.
Resumen:	Propafenone is mainly metabolized by CYP2D6 to form 5-hydroxypropafenone (5-OHP) and to a minor extent by CYP1A2 and CYP3A4 to form N-depropylpropafenone (N-DPP). The in vitro inhibitory effect of selective serotonin reuptake inhibitors (SSRIs) on the formation of both metabolites was studied, using human liver microsomes.
Link:	./index.php?lvl=notice_display&id=31179