[artículo] 
inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 435-444

Título :	Inhibition of cytochrome p450 2d6 modifies codeine abuse liability
Tipo de documento:	texto impreso
Autores:	Kalyani Kathiramalainathan, Autor ; Howard L. Kaplan, Autor ; Myroslava K. Romach, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 435-444
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Codeína, Inhibidores del citocromo P-450 CYP2D6, Inhibidores enzimáticos, Narcóticos, Trastornos relacionados con los opioides, Efectos de la pupila, Quinidina.
Resumen:	Oral codeine preparations, widely used for analgesia and cough suppression, are abused by some individuals for their mood-altering properties. The enzymatic O-demethylation of codeine is catalyzed by cytochrome P450 2D6 (CYP2D6), leading to the production of metabolites (morphine, morphine-6-glucuronide) that are pharmacologically more potent than codeine. A placebo-controlled, single-blind study was conducted to characterize the subjective effects of codeine associated with abuse liability and to determine the importance of metabolic O-demethylation to codeine abuse liability.
Link:	./index.php?lvl=notice_display&id=31180

[artículo] Inhibition of cytochrome p450 2d6 modifies codeine abuse liability [texto impreso] / Kalyani Kathiramalainathan, Autor ; Howard L. Kaplan, Autor ; Myroslava K. Romach, Autor . - 2023 . - pp. 435-444.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 435-444

Palabras clave:	Codeína, Inhibidores del citocromo P-450 CYP2D6, Inhibidores enzimáticos, Narcóticos, Trastornos relacionados con los opioides, Efectos de la pupila, Quinidina.
Resumen:	Oral codeine preparations, widely used for analgesia and cough suppression, are abused by some individuals for their mood-altering properties. The enzymatic O-demethylation of codeine is catalyzed by cytochrome P450 2D6 (CYP2D6), leading to the production of metabolites (morphine, morphine-6-glucuronide) that are pharmacologically more potent than codeine. A placebo-controlled, single-blind study was conducted to characterize the subjective effects of codeine associated with abuse liability and to determine the importance of metabolic O-demethylation to codeine abuse liability.
Link:	./index.php?lvl=notice_display&id=31180