[artículo] 
inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 3 (Junio) . - pp. 347-349

Título :	Single dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers
Tipo de documento:	texto impreso
Autores:	C. Lindsay DeVane, Autor ; John C. Markowitz, Autor ; Stanley W. Carson, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 347-349
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Estimulantes del sistema nervioso central, Citocromo P-450 CYP2D6, Inhibidores del citocromo P-450 CYP2D6, Espectrometría de masas, Metilfenidato.
Resumen:	Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 (CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had no significant effect on the pharmacokinetics of either MPH or ritalinic acid, its major metabolite, in either group of CYP2D6 metabolizers.
Link:	./index.php?lvl=notice_display&id=31193

[artículo] Single dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers [texto impreso] / C. Lindsay DeVane, Autor ; John C. Markowitz, Autor ; Stanley W. Carson, Autor . - 2023 . - pp. 347-349.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 3 (Junio) . - pp. 347-349

Palabras clave:	Estimulantes del sistema nervioso central, Citocromo P-450 CYP2D6, Inhibidores del citocromo P-450 CYP2D6, Espectrometría de masas, Metilfenidato.
Resumen:	Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 (CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had no significant effect on the pharmacokinetics of either MPH or ritalinic acid, its major metabolite, in either group of CYP2D6 metabolizers.
Link:	./index.php?lvl=notice_display&id=31193