[artículo] 
inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 35-42

Título :	Fluvoxamine-clozapine drug interaction: inhibition in vitro of five cytochrome p450 isoforms involved in clozapine metabolism
Tipo de documento:	texto impreso
Autores:	Ole V. Olesen, Autor ; Kristian Linnet, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 35-42
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Clozapina, Sistema enzimático citocromo P-450, Interacción medicamentosa, Fluvoxamina, Isoenzimas, Inhibidores selectivos de la recaptación de serotonina.
Resumen:	Administration of fluvoxamine to patients receiving clozapine therapy may increase the steady-state serum concentrations of clozapine by a factor of 5 to 10. The authors undertook in vitro studies to disclose the mechanism behind this clinically important interaction. In a human liver microsome preparation, fluvoxamine showed a concentration-dependent inhibition of clozapine N-demethylation.
Link:	./index.php?lvl=notice_display&id=31229

[artículo] Fluvoxamine-clozapine drug interaction: inhibition in vitro of five cytochrome p450 isoforms involved in clozapine metabolism [texto impreso] / Ole V. Olesen, Autor ; Kristian Linnet, Autor . - 2023 . - pp. 35-42.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 35-42

Palabras clave:	Clozapina, Sistema enzimático citocromo P-450, Interacción medicamentosa, Fluvoxamina, Isoenzimas, Inhibidores selectivos de la recaptación de serotonina.
Resumen:	Administration of fluvoxamine to patients receiving clozapine therapy may increase the steady-state serum concentrations of clozapine by a factor of 5 to 10. The authors undertook in vitro studies to disclose the mechanism behind this clinically important interaction. In a human liver microsome preparation, fluvoxamine showed a concentration-dependent inhibition of clozapine N-demethylation.
Link:	./index.php?lvl=notice_display&id=31229