[artículo]
| Título : |
Comparison of central and peripheral pharmacologic effects of biperiden and trihexyphenidyl in human volunteers |
| Tipo de documento: |
texto impreso |
| Autores: |
Sally K. Guthrie, Autor ; Laura Manzey, Autor ; Doneka Scott, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 77-83 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Biperideno, Hemodinámica, Recuerdo mental, Antagonistas muscarínicos, Rendimiento psicomotor, Salivación. |
| Resumen: |
In this double-blind, randomized study, indices of central (memory, sedation) and peripheral (salivation, ratio of R-R interval on electrocardiogram) muscarinic function were evaluated in 14 healthy volunteers who received trihexyphenidyl, biperiden, and placebo. Additionally, serum drug levels were obtained 2 hours after oral administration. All subjects participated in three study sessions. During each session, subjects received two doses of biperiden (4 mg), trihexyphenidyl (5 mg), or placebo, and four series of tests were administered. |
| Link: |
./index.php?lvl=notice_display&id=31235 |
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 77-83
[artículo] Comparison of central and peripheral pharmacologic effects of biperiden and trihexyphenidyl in human volunteers [texto impreso] / Sally K. Guthrie, Autor ; Laura Manzey, Autor ; Doneka Scott, Autor . - 2023 . - pp. 77-83. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 77-83
| Palabras clave: |
Biperideno, Hemodinámica, Recuerdo mental, Antagonistas muscarínicos, Rendimiento psicomotor, Salivación. |
| Resumen: |
In this double-blind, randomized study, indices of central (memory, sedation) and peripheral (salivation, ratio of R-R interval on electrocardiogram) muscarinic function were evaluated in 14 healthy volunteers who received trihexyphenidyl, biperiden, and placebo. Additionally, serum drug levels were obtained 2 hours after oral administration. All subjects participated in three study sessions. During each session, subjects received two doses of biperiden (4 mg), trihexyphenidyl (5 mg), or placebo, and four series of tests were administered. |
| Link: |
./index.php?lvl=notice_display&id=31235 |
|
Comparison of central and peripheral pharmacologic effects of biperiden and trihexyphenidyl in human volunteers en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)
