[artículo] 
inThe American Journal of Psychiatry > Año 2025 - Vol. 182 - No.4 (Abril) . - pp. 389–400

Título :	Kynurenic acid and promotion of activity-dependent synapse elimination in schizophrenia
Tipo de documento:	texto impreso
Autores:	Funda Orhan, Autor ; Susmita Malwade, Autor ; Neda Khanlarkhani, Autor
Fecha de publicación:	2025
Artículo en la página:	pp. 389–400
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Células gliales, Células madre pluripotentes inducidas, Esquizofrenia, Eliminación sináptica, Metabolismo del triptófano.
Resumen:	Schizophrenia is a neurodevelopmental disorder characterized by an excessive loss of synapses. Kynurenic acid (KYNA), a neuroactive metabolite of tryptophan along the kynurenine pathway, can induce schizophrenia-related phenotypes in rodents, and clinical studies have revealed elevated KYNA levels in the CNS of individuals with schizophrenia.
Link:	./index.php?lvl=notice_display&id=31599

[artículo] Kynurenic acid and promotion of activity-dependent synapse elimination in schizophrenia [texto impreso] / Funda Orhan, Autor ; Susmita Malwade, Autor ; Neda Khanlarkhani, Autor . - 2025 . - pp. 389–400.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in The American Journal of Psychiatry > Año 2025 - Vol. 182 - No.4 (Abril) . - pp. 389–400

Palabras clave:	Células gliales, Células madre pluripotentes inducidas, Esquizofrenia, Eliminación sináptica, Metabolismo del triptófano.
Resumen:	Schizophrenia is a neurodevelopmental disorder characterized by an excessive loss of synapses. Kynurenic acid (KYNA), a neuroactive metabolite of tryptophan along the kynurenine pathway, can induce schizophrenia-related phenotypes in rodents, and clinical studies have revealed elevated KYNA levels in the CNS of individuals with schizophrenia.
Link:	./index.php?lvl=notice_display&id=31599