Artículos

Harmonizing the neurobiology and treatment of obsessive-compulsive disorder / Wayne K Goodman en The American Journal of Psychiatry, Año 2021 - Vol. 178 - No.1 (Enero)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 17-29 Título : Harmonizing the neurobiology and treatment of obsessive-compulsive disorder Tipo de documento: texto impreso Autores: Wayne K Goodman, Autor ; Eric A. Storch, Autor ; Sameer A. Sheth, Autor Fecha de publicación: 2021 Artículo en la página: pp. 17-29 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: TOC, PANDAS, Genética, Genómica, Neuroestimulación, Neurobiología, Prevención de respuesta a la exposición, Serotonina, Glutamato, Estimulación cerebral profunda, Estimulación magnética transcraneal. Resumen: Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling disorder. The only established first-line treatments for OCD are exposure and response prevention, and serotonin reuptake inhibitor medications (SRIs). However, a subset of patients fails to respond to either modality, and few experience complete remission. Link: ./index.php?lvl=notice_display&id=26860 [artículo] Harmonizing the neurobiology and treatment of obsessive-compulsive disorder [texto impreso] / Wayne K Goodman, Autor ; Eric A. Storch, Autor ; Sameer A. Sheth, Autor . - 2021 . - pp. 17-29. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 17-29 Palabras clave: TOC, PANDAS, Genética, Genómica, Neuroestimulación, Neurobiología, Prevención de respuesta a la exposición, Serotonina, Glutamato, Estimulación cerebral profunda, Estimulación magnética transcraneal. Resumen: Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling disorder. The only established first-line treatments for OCD are exposure and response prevention, and serotonin reuptake inhibitor medications (SRIs). However, a subset of patients fails to respond to either modality, and few experience complete remission. Link: ./index.php?lvl=notice_display&id=26860

Autism spectrum disorder genetics and the search for pathological mechanisms / Devanand S. Manoli en The American Journal of Psychiatry, Año 2021 - Vol. 178 - No.1 (Enero)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 30-38 Título : Autism spectrum disorder genetics and the search for pathological mechanisms Tipo de documento: texto impreso Autores: Devanand S. Manoli, Autor ; Matthew W. State, Autor Fecha de publicación: 2021 Artículo en la página: pp. 30-38 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno del espectro autista, Trastornos del neurodesarrollo, Genética / Genómica Resumen: Recent progress in the identification of genes and genomic regions contributing to autism spectrum disorder (ASD) has had a broad impact on our understanding of the nature of genetic risk for a range of psychiatric disorders, on our understanding of ASD biology, and on defining the key challenges now facing the field in efforts to translate gene discovery into an actionable understanding of pathology. Link: ./index.php?lvl=notice_display&id=26861 [artículo] Autism spectrum disorder genetics and the search for pathological mechanisms [texto impreso] / Devanand S. Manoli, Autor ; Matthew W. State, Autor . - 2021 . - pp. 30-38. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 30-38 Palabras clave: Trastorno del espectro autista, Trastornos del neurodesarrollo, Genética / Genómica Resumen: Recent progress in the identification of genes and genomic regions contributing to autism spectrum disorder (ASD) has had a broad impact on our understanding of the nature of genetic risk for a range of psychiatric disorders, on our understanding of ASD biology, and on defining the key challenges now facing the field in efforts to translate gene discovery into an actionable understanding of pathology. Link: ./index.php?lvl=notice_display&id=26861

Treatment-specific associations between brain activation and symptom reduction in ocd following cbt / Luke J. Norman en The American Journal of Psychiatry, Año 2021 - Vol. 178 - No.1 (Enero)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 39-47 Título : Treatment-specific associations between brain activation and symptom reduction in ocd following cbt : a randomized fmri trial Tipo de documento: texto impreso Autores: Luke J. Norman, Autor ; Kristin A. Mannella, Autor ; Huan Yang, Autor Fecha de publicación: 2021 Artículo en la página: pp. 39-47 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno obsesivo compulsivo, Terapia de conducta cognitiva, Control inhibitorio, Procesamiento de recompensas, fMRI Resumen: The authors sought to examine whether brain activity is associated with treatment response to cognitive-behavioral therapy (CBT) in adolescents and adults with obsessive-compulsive disorder (OCD), and whether any associations are treatment specific relative to an active control psychotherapy (stress management therapy; SMT). Link: ./index.php?lvl=notice_display&id=26862 [artículo] Treatment-specific associations between brain activation and symptom reduction in ocd following cbt : a randomized fmri trial [texto impreso] / Luke J. Norman, Autor ; Kristin A. Mannella, Autor ; Huan Yang, Autor . - 2021 . - pp. 39-47. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 39-47 Palabras clave: Trastorno obsesivo compulsivo, Terapia de conducta cognitiva, Control inhibitorio, Procesamiento de recompensas, fMRI Resumen: The authors sought to examine whether brain activity is associated with treatment response to cognitive-behavioral therapy (CBT) in adolescents and adults with obsessive-compulsive disorder (OCD), and whether any associations are treatment specific relative to an active control psychotherapy (stress management therapy; SMT). Link: ./index.php?lvl=notice_display&id=26862

Antibodies from children with pandas bind specifically to striatal cholinergic interneurons and alter their activity / Jian Xu en The American Journal of Psychiatry, Año 2021 - Vol. 178 - No.1 (Enero)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 48-64 Título : Antibodies from children with pandas bind specifically to striatal cholinergic interneurons and alter their activity Tipo de documento: texto impreso Autores: Jian Xu, Autor ; Rong-Jian Liu, Autor ; Shaylyn Fahey, Autor Fecha de publicación: 2021 Artículo en la página: pp. 48-64 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: PANDAS, PAN, Trastorno obsesivo compulsivo, Ganglios basales, Interneurona, Interneurona colinérgica Resumen: Pediatric obsessive-compulsive disorder (OCD) sometimes appears rapidly, even overnight, often after an infection. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAS, describes such a situation after infection with Streptococcus pyogenes. PANDAS may result from induced autoimmunity against brain antigens, although this remains unproven. Link: ./index.php?lvl=notice_display&id=26863 [artículo] Antibodies from children with pandas bind specifically to striatal cholinergic interneurons and alter their activity [texto impreso] / Jian Xu, Autor ; Rong-Jian Liu, Autor ; Shaylyn Fahey, Autor . - 2021 . - pp. 48-64. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 48-64 Palabras clave: PANDAS, PAN, Trastorno obsesivo compulsivo, Ganglios basales, Interneurona, Interneurona colinérgica Resumen: Pediatric obsessive-compulsive disorder (OCD) sometimes appears rapidly, even overnight, often after an infection. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAS, describes such a situation after infection with Streptococcus pyogenes. PANDAS may result from induced autoimmunity against brain antigens, although this remains unproven. Link: ./index.php?lvl=notice_display&id=26863

Diagnostic classification for human autism and obsessive-compulsive disorder based on machine learning from a primate genetic model / Yafeng Zhan en The American Journal of Psychiatry, Año 2021 - Vol. 178 - No.1 (Enero)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 65-76 Título : Diagnostic classification for human autism and obsessive-compulsive disorder based on machine learning from a primate genetic model Tipo de documento: texto impreso Autores: Yafeng Zhan, Autor ; Jianze Wei, Autor ; Jian Liang, Autor Fecha de publicación: 2021 Artículo en la página: pp. 65-76 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Mono transgénico, fMRI en estado de reposo, Desorden del espectro autista, Trastorno obsesivo compulsivo, Corteza prefrontal ventrolateral Resumen: Psychiatric disorders commonly comprise comorbid symptoms, such as autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD), raising controversies over accurate diagnosis and overlap of their neural underpinnings. Link: ./index.php?lvl=notice_display&id=26864 [artículo] Diagnostic classification for human autism and obsessive-compulsive disorder based on machine learning from a primate genetic model [texto impreso] / Yafeng Zhan, Autor ; Jianze Wei, Autor ; Jian Liang, Autor . - 2021 . - pp. 65-76. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 65-76 Palabras clave: Mono transgénico, fMRI en estado de reposo, Desorden del espectro autista, Trastorno obsesivo compulsivo, Corteza prefrontal ventrolateral Resumen: Psychiatric disorders commonly comprise comorbid symptoms, such as autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD), raising controversies over accurate diagnosis and overlap of their neural underpinnings. Link: ./index.php?lvl=notice_display&id=26864

A genetics-first approach to dissecting the heterogeneity of autism / Samuel J. R. A. Chawner en The American Journal of Psychiatry, Año 2021 - Vol. 178 - No.1 (Enero)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 77-86 Título : A genetics-first approach to dissecting the heterogeneity of autism : phenotypic comparison of autism risk copy number variants Tipo de documento: texto impreso Autores: Samuel J. R. A. Chawner, Autor ; Joanne L. Doherty, Autor ; Richard J. L. Anney, Autor Fecha de publicación: 2021 Artículo en la página: pp. 77-86 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Autismo, Genética, Copiar variantes de números Resumen: Certain copy number variants (CNVs) greatly increase the risk of autism. The authors conducted a genetics-first study to investigate whether heterogeneity in the clinical presentation of autism is underpinned by specific genotype-phenotype relationships. Link: ./index.php?lvl=notice_display&id=26865 [artículo] A genetics-first approach to dissecting the heterogeneity of autism : phenotypic comparison of autism risk copy number variants [texto impreso] / Samuel J. R. A. Chawner, Autor ; Joanne L. Doherty, Autor ; Richard J. L. Anney, Autor . - 2021 . - pp. 77-86. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 77-86 Palabras clave: Autismo, Genética, Copiar variantes de números Resumen: Certain copy number variants (CNVs) greatly increase the risk of autism. The authors conducted a genetics-first study to investigate whether heterogeneity in the clinical presentation of autism is underpinned by specific genotype-phenotype relationships. Link: ./index.php?lvl=notice_display&id=26865

Effect sizes of deletions and duplications on autism risk across the genome / Elise Douard en The American Journal of Psychiatry, Año 2021 - Vol. 178 - No.1 (Enero)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 87-98 Título : Effect sizes of deletions and duplications on autism risk across the genome Tipo de documento: texto impreso Autores: Elise Douard, Autor ; Abderrahim Zeribi, Autor ; Catherine Schramm, Autor Fecha de publicación: 2021 Artículo en la página: pp. 87-98 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno del espectro autista, Copiar variantes de números, IQ Resumen: Deleterious copy number variants (CNVs) are identified in up to 20% of individuals with autism. However, levels of autism risk conferred by most rare CNVs remain unknown. The authors recently developed statistical models to estimate the effect size on IQ of all CNVs, including undocumented ones. In this study, the authors extended this model to autism susceptibility. Link: ./index.php?lvl=notice_display&id=26866 [artículo] Effect sizes of deletions and duplications on autism risk across the genome [texto impreso] / Elise Douard, Autor ; Abderrahim Zeribi, Autor ; Catherine Schramm, Autor . - 2021 . - pp. 87-98. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 87-98 Palabras clave: Trastorno del espectro autista, Copiar variantes de números, IQ Resumen: Deleterious copy number variants (CNVs) are identified in up to 20% of individuals with autism. However, levels of autism risk conferred by most rare CNVs remain unknown. The authors recently developed statistical models to estimate the effect size on IQ of all CNVs, including undocumented ones. In this study, the authors extended this model to autism susceptibility. Link: ./index.php?lvl=notice_display&id=26866