Artículos

Putting genetics to work in the psychiatric clinic / Francis J. McMahon en The American Journal of Psychiatry, Año 2022 Vol. 179 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 182-188 Título : Putting genetics to work in the psychiatric clinic Tipo de documento: texto impreso Autores: Francis J. McMahon, Autor Fecha de publicación: 2022 Artículo en la página: pp. 182-188 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Genética - genómica, Investigación traslacional Resumen: The rapid progress in psychiatric genetics over the past 10 years, while exciting from a research perspective, has not yet had an impact on clinical practice. How will we really be able to put genetics to work in the psychiatric clinic? This overview will attempt to answer this question. A survey of widely used methods and major study designs highlights key findings that have emerged so far. Link: ./index.php?lvl=notice_display&id=28396 [artículo] Putting genetics to work in the psychiatric clinic [texto impreso] / Francis J. McMahon, Autor . - 2022 . - pp. 182-188. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 182-188 Palabras clave: Genética - genómica, Investigación traslacional Resumen: The rapid progress in psychiatric genetics over the past 10 years, while exciting from a research perspective, has not yet had an impact on clinical practice. How will we really be able to put genetics to work in the psychiatric clinic? This overview will attempt to answer this question. A survey of widely used methods and major study designs highlights key findings that have emerged so far. Link: ./index.php?lvl=notice_display&id=28396

Genes to mental health (g2mh) / Sébastien Jacquemont en The American Journal of Psychiatry, Año 2022 Vol. 179 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 189-203 Título : Genes to mental health (g2mh) : a framework to map the combined effects of rare and common variants on dimensions of cognition and psychopathology Tipo de documento: texto impreso Autores: Sébastien Jacquemont, Autor ; Guillaume Huguet, Autor ; Marieke Klein, Autor Fecha de publicación: 2022 Artículo en la página: pp. 189-203 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Genética - genómica, Trastornos del neurodesarrollo, Espectro de esquizofrenia y otros trastornos psicóticos, Trastorno del espectro autista, Discapacidades intelectuales, Diagnóstico y Clasificación. Resumen: Rare genomic disorders (RGDs) confer elevated risk for neurodevelopmental psychiatric disorders. In this era of intense genomics discoveries, the landscape of RGDs is rapidly evolving. However, there has not been comparable progress to date in scalable, harmonized phenotyping methods. As a result, beyond associations with categorical diagnoses, the effects on dimensional traits remain unclear for many RGDs. Link: ./index.php?lvl=notice_display&id=28397 [artículo] Genes to mental health (g2mh) : a framework to map the combined effects of rare and common variants on dimensions of cognition and psychopathology [texto impreso] / Sébastien Jacquemont, Autor ; Guillaume Huguet, Autor ; Marieke Klein, Autor . - 2022 . - pp. 189-203. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 189-203 Palabras clave: Genética - genómica, Trastornos del neurodesarrollo, Espectro de esquizofrenia y otros trastornos psicóticos, Trastorno del espectro autista, Discapacidades intelectuales, Diagnóstico y Clasificación. Resumen: Rare genomic disorders (RGDs) confer elevated risk for neurodevelopmental psychiatric disorders. In this era of intense genomics discoveries, the landscape of RGDs is rapidly evolving. However, there has not been comparable progress to date in scalable, harmonized phenotyping methods. As a result, beyond associations with categorical diagnoses, the effects on dimensional traits remain unclear for many RGDs. Link: ./index.php?lvl=notice_display&id=28397

Aberrant developmental patterns of gamma-band response and long-range communication disruption in youths with 22q11.2 deletion syndrome / Valentina Mancini en The American Journal of Psychiatry, Año 2022 Vol. 179 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 204-215 Título : Aberrant developmental patterns of gamma-band response and long-range communication disruption in youths with 22q11.2 deletion syndrome Tipo de documento: texto impreso Autores: Valentina Mancini, Autor ; Vincent Rochas, Autor ; Martin Seeber, Autor Fecha de publicación: 2022 Artículo en la página: pp. 204-215 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Oscilaciones de banda gamma, Oscilaciones de banda theta, Psicosis, Acoplamiento Fase-Amplitud, Adolescencia, SD22q11 Resumen: Brain oscillations play a pivotal role in synchronizing responses of local and global ensembles of neurons. Patients with schizophrenia exhibit impairments in oscillatory response, which are thought to stem from abnormal maturation during critical developmental stages. Studying individuals at genetic risk for psychosis, such as 22q11.2 deletion carriers, from childhood to adulthood may provide insights into developmental abnormalities. Link: ./index.php?lvl=notice_display&id=28398 [artículo] Aberrant developmental patterns of gamma-band response and long-range communication disruption in youths with 22q11.2 deletion syndrome [texto impreso] / Valentina Mancini, Autor ; Vincent Rochas, Autor ; Martin Seeber, Autor . - 2022 . - pp. 204-215. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 204-215 Palabras clave: Oscilaciones de banda gamma, Oscilaciones de banda theta, Psicosis, Acoplamiento Fase-Amplitud, Adolescencia, SD22q11 Resumen: Brain oscillations play a pivotal role in synchronizing responses of local and global ensembles of neurons. Patients with schizophrenia exhibit impairments in oscillatory response, which are thought to stem from abnormal maturation during critical developmental stages. Studying individuals at genetic risk for psychosis, such as 22q11.2 deletion carriers, from childhood to adulthood may provide insights into developmental abnormalities. Link: ./index.php?lvl=notice_display&id=28398

The genetic architecture of obsessive-compulsive disorder / Behrang Mahjani en The American Journal of Psychiatry, Año 2022 Vol. 179 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 216-225 Título : The genetic architecture of obsessive-compulsive disorder : contribution of liability to ocd from alleles across the frequency spectrum Tipo de documento: texto impreso Autores: Behrang Mahjani, Autor ; Lambertus Klei, Autor ; Manuel Mattheisen, Autor Fecha de publicación: 2022 Artículo en la página: pp. 216-225 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno obsesivo compulsivo, Heredabilidad, Genética Resumen: Obsessive-compulsive disorder (OCD) is known to be substantially heritable; however, the contribution of genetic variation across the allele frequency spectrum to this heritability remains uncertain. The authors used two new homogeneous cohorts to estimate the heritability of OCD from inherited genetic variation and contrasted the results with those of previous studies. Link: ./index.php?lvl=notice_display&id=28399 [artículo] The genetic architecture of obsessive-compulsive disorder : contribution of liability to ocd from alleles across the frequency spectrum [texto impreso] / Behrang Mahjani, Autor ; Lambertus Klei, Autor ; Manuel Mattheisen, Autor . - 2022 . - pp. 216-225. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 216-225 Palabras clave: Trastorno obsesivo compulsivo, Heredabilidad, Genética Resumen: Obsessive-compulsive disorder (OCD) is known to be substantially heritable; however, the contribution of genetic variation across the allele frequency spectrum to this heritability remains uncertain. The authors used two new homogeneous cohorts to estimate the heritability of OCD from inherited genetic variation and contrasted the results with those of previous studies. Link: ./index.php?lvl=notice_display&id=28399

Genetics and brain transcriptomics of completed suicide / Giovanna Punzi en The American Journal of Psychiatry, Año 2022 Vol. 179 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 226-241 Título : Genetics and brain transcriptomics of completed suicide Tipo de documento: texto impreso Autores: Giovanna Punzi, Autor ; Gianluca Ursini, Autor ; Qiang Chen, Autor Fecha de publicación: 2022 Artículo en la página: pp. 226-241 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Método de Suicidio, Cerebro post mortem, Secuenciación de ARN, Riesgo Genómico, Señalización purinérgica, Mitocondrias Resumen: The authors sought to study the transcriptomic and genomic features of completed suicide by parsing the method chosen, to capture molecular correlates of the distinctive frame of mind of individuals who die by suicide, while reducing heterogeneity. Link: ./index.php?lvl=notice_display&id=28400 [artículo] Genetics and brain transcriptomics of completed suicide [texto impreso] / Giovanna Punzi, Autor ; Gianluca Ursini, Autor ; Qiang Chen, Autor . - 2022 . - pp. 226-241. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 226-241 Palabras clave: Método de Suicidio, Cerebro post mortem, Secuenciación de ARN, Riesgo Genómico, Señalización purinérgica, Mitocondrias Resumen: The authors sought to study the transcriptomic and genomic features of completed suicide by parsing the method chosen, to capture molecular correlates of the distinctive frame of mind of individuals who die by suicide, while reducing heterogeneity. Link: ./index.php?lvl=notice_display&id=28400

Interindividual differences in cortical thickness and their genomic underpinnings in autism spectrum disorder / Christine Ecker en The American Journal of Psychiatry, Año 2022 Vol. 179 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 242-254 Título : Interindividual differences in cortical thickness and their genomic underpinnings in autism spectrum disorder Tipo de documento: texto impreso Autores: Christine Ecker, Autor ; Charlotte M. Pretzsch, Autor ; Anke Bletsch, Autor Fecha de publicación: 2022 Artículo en la página: pp. 242-254 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno del espectro autista, Trastornos del neurodesarrollo, Neuroanatomía, Neuroimagen, Espesor cortical, Genética Resumen: Autism spectrum disorder (ASD) is accompanied by highly individualized neuroanatomical deviations that potentially map onto distinct genotypes and clinical phenotypes. This study aimed to link differences in brain anatomy to specific biological pathways to pave the way toward targeted therapeutic interventions. Link: ./index.php?lvl=notice_display&id=28401 [artículo] Interindividual differences in cortical thickness and their genomic underpinnings in autism spectrum disorder [texto impreso] / Christine Ecker, Autor ; Charlotte M. Pretzsch, Autor ; Anke Bletsch, Autor . - 2022 . - pp. 242-254. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 Vol. 179 - No. 3 (Marzo) . - pp. 242-254 Palabras clave: Trastorno del espectro autista, Trastornos del neurodesarrollo, Neuroanatomía, Neuroimagen, Espesor cortical, Genética Resumen: Autism spectrum disorder (ASD) is accompanied by highly individualized neuroanatomical deviations that potentially map onto distinct genotypes and clinical phenotypes. This study aimed to link differences in brain anatomy to specific biological pathways to pave the way toward targeted therapeutic interventions. Link: ./index.php?lvl=notice_display&id=28401