Artículos

Transforming discoveries about cortical microcircuits and gamma oscillations into new treatments for cognitive deficits in schizophrenia / Vikaas S. Sohal en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 4 (Abril)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 267–276 Título : Transforming discoveries about cortical microcircuits and gamma oscillations into new treatments for cognitive deficits in schizophrenia Tipo de documento: texto impreso Autores: Vikaas S. Sohal, Autor Fecha de publicación: 2022 Artículo en la página: pp. 267–276 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Espectro de esquizofrenia y otros trastornos psicóticos, Neurocircuitos Resumen: The major cause of disability in schizophrenia is cognitive impairment, which remains largely refractory to existing treatments. This reflects the fact that antipsychotics and other therapies have not been designed to address specific brain abnormalities that cause cognitive impairment. This overview proposes that understanding how specific cellular and synaptic loci within cortical microcircuits contribute to cortical gamma oscillations may reveal treatments for cognitive impairment. Link: ./index.php?lvl=notice_display&id=28451 [artículo] Transforming discoveries about cortical microcircuits and gamma oscillations into new treatments for cognitive deficits in schizophrenia [texto impreso] / Vikaas S. Sohal, Autor . - 2022 . - pp. 267–276. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 267–276 Palabras clave: Espectro de esquizofrenia y otros trastornos psicóticos, Neurocircuitos Resumen: The major cause of disability in schizophrenia is cognitive impairment, which remains largely refractory to existing treatments. This reflects the fact that antipsychotics and other therapies have not been designed to address specific brain abnormalities that cause cognitive impairment. This overview proposes that understanding how specific cellular and synaptic loci within cortical microcircuits contribute to cortical gamma oscillations may reveal treatments for cognitive impairment. Link: ./index.php?lvl=notice_display&id=28451

Synaptic variability and cortical gamma oscillation power in schizophrenia / Daniel W. Chung en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 4 (Abril)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 277-287 Título : Synaptic variability and cortical gamma oscillation power in schizophrenia Tipo de documento: texto impreso Autores: Daniel W. Chung, Autor ; Matthew A. Geramita, Autor ; David A. Lewis, Autor Fecha de publicación: 2022 Artículo en la página: pp. 277-287 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Neurocircuitos, Neurociencia, Espectro de esquizofrenia y otros trastornos psicóticos, Investigación Traslacional Resumen: Cognitive impairments in schizophrenia are associated with lower gamma oscillation power in the prefrontal cortex (PFC). Gamma power depends in part on excitatory drive to fast-spiking parvalbumin interneurons (PVIs). Excitatory drive to cortical neurons varies in strength, which could affect how these neurons regulate network oscillations. The authors investigated whether variability in excitatory synaptic strength across PVIs could contribute to lower prefrontal gamma power in schizophrenia. Link: ./index.php?lvl=notice_display&id=28452 [artículo] Synaptic variability and cortical gamma oscillation power in schizophrenia [texto impreso] / Daniel W. Chung, Autor ; Matthew A. Geramita, Autor ; David A. Lewis, Autor . - 2022 . - pp. 277-287. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 277-287 Palabras clave: Neurocircuitos, Neurociencia, Espectro de esquizofrenia y otros trastornos psicóticos, Investigación Traslacional Resumen: Cognitive impairments in schizophrenia are associated with lower gamma oscillation power in the prefrontal cortex (PFC). Gamma power depends in part on excitatory drive to fast-spiking parvalbumin interneurons (PVIs). Excitatory drive to cortical neurons varies in strength, which could affect how these neurons regulate network oscillations. The authors investigated whether variability in excitatory synaptic strength across PVIs could contribute to lower prefrontal gamma power in schizophrenia. Link: ./index.php?lvl=notice_display&id=28452

20 year prospective, sequential follow up study of heterogeneity in associations of duration of untreated psychosis with symptoms, functioning, and quality of life following first episode psychosis / Donal O’Keeffe en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 4 (Abril)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 288-297 Título : 20 year prospective, sequential follow up study of heterogeneity in associations of duration of untreated psychosis with symptoms, functioning, and quality of life following first episode psychosis Tipo de documento: texto impreso Autores: Donal O’Keeffe, Autor ; Anthony Kinsella, Autor ; John L. Waddington, Autor Fecha de publicación: 2022 Artículo en la página: pp. 288-297 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Psicosis de primer episodio, Enfermedad psicótica, Duración de la psicosis no tratada, Sintomatología, Funcionamiento, Calidad de vida, Heterogeneidad. Resumen: Determining the extent to which relationships between duration of untreated psychosis (DUP) and outcome endure longitudinally across the lifetime course of psychotic illness requires prospective, systematic studies of epidemiologically representative incidence cohorts across decades. Transience, persistence, or heterogeneity in associations between DUP and distinct outcome domains are yet to be investigated over such time frames. Link: ./index.php?lvl=notice_display&id=28453 [artículo] 20 year prospective, sequential follow up study of heterogeneity in associations of duration of untreated psychosis with symptoms, functioning, and quality of life following first episode psychosis [texto impreso] / Donal O’Keeffe, Autor ; Anthony Kinsella, Autor ; John L. Waddington, Autor . - 2022 . - pp. 288-297. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 288-297 Palabras clave: Psicosis de primer episodio, Enfermedad psicótica, Duración de la psicosis no tratada, Sintomatología, Funcionamiento, Calidad de vida, Heterogeneidad. Resumen: Determining the extent to which relationships between duration of untreated psychosis (DUP) and outcome endure longitudinally across the lifetime course of psychotic illness requires prospective, systematic studies of epidemiologically representative incidence cohorts across decades. Transience, persistence, or heterogeneity in associations between DUP and distinct outcome domains are yet to be investigated over such time frames. Link: ./index.php?lvl=notice_display&id=28453

Association of medication treatment for opioid use disorder with suicide mortality / Bradley V. Watts en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 4 (Abril)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 298-304 Título : Association of medication treatment for opioid use disorder with suicide mortality Tipo de documento: texto impreso Autores: Bradley V. Watts, Autor ; Daniel J. Gottlieb, Autor ; Riblet, Natalie B. V., Autor Fecha de publicación: 2022 Artículo en la página: pp. 298-304 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Suicidio y autoagresión, Trastornos adictivos relacionados con sustancias, Opioides, Tratamiento asistido por medicamentos Resumen: Understanding the effectiveness of medication treatment for opioid use disorder to decrease the risk of suicide mortality may inform clinical and policy decisions. The authors sought to describe the effect of medications for opioid use disorder (MOUD) on risk of suicide mortality. Link: ./index.php?lvl=notice_display&id=28454 [artículo] Association of medication treatment for opioid use disorder with suicide mortality [texto impreso] / Bradley V. Watts, Autor ; Daniel J. Gottlieb, Autor ; Riblet, Natalie B. V., Autor . - 2022 . - pp. 298-304. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 298-304 Palabras clave: Suicidio y autoagresión, Trastornos adictivos relacionados con sustancias, Opioides, Tratamiento asistido por medicamentos Resumen: Understanding the effectiveness of medication treatment for opioid use disorder to decrease the risk of suicide mortality may inform clinical and policy decisions. The authors sought to describe the effect of medications for opioid use disorder (MOUD) on risk of suicide mortality. Link: ./index.php?lvl=notice_display&id=28454

Effects of county-level opioid dispensing rates on individual-level patterns of prescription opioid and heroin consumption / Mike Vuolo en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 4 (Abril)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 305-311 Título : Effects of county-level opioid dispensing rates on individual-level patterns of prescription opioid and heroin consumption : evidence from national U.S. Data Tipo de documento: texto impreso Autores: Mike Vuolo, Autor ; Brian C. Kelly, Autor Fecha de publicación: 2022 Artículo en la página: pp. 305-311 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Opioides, Trastornos adictivos relacionados con sustancias, Heroína, Opioides recetados. Resumen: The authors examined directly whether county-level changes in opioid dispensing rates affect individual-level prescription opioid misuse, frequency of use, and dependence, as well as the same outcomes for heroin. Link: ./index.php?lvl=notice_display&id=28455 [artículo] Effects of county-level opioid dispensing rates on individual-level patterns of prescription opioid and heroin consumption : evidence from national U.S. Data [texto impreso] / Mike Vuolo, Autor ; Brian C. Kelly, Autor . - 2022 . - pp. 305-311. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 4 (Abril) . - pp. 305-311 Palabras clave: Opioides, Trastornos adictivos relacionados con sustancias, Heroína, Opioides recetados. Resumen: The authors examined directly whether county-level changes in opioid dispensing rates affect individual-level prescription opioid misuse, frequency of use, and dependence, as well as the same outcomes for heroin. Link: ./index.php?lvl=notice_display&id=28455