Artículos

Using stem cell models to explore the genetics underlying psychiatric disorders / Kristen J. Brennand en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 322-328 Título : Using stem cell models to explore the genetics underlying psychiatric disorders : linking risk variants, genes, and biology in brain disease Tipo de documento: texto impreso Autores: Kristen J. Brennand, Autor Fecha de publicación: 2022 Artículo en la página: pp. 322-328 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Genética - Genómica, Biología, Esquizofrenia Resumen: There is an urgent and unmet need to advance our ability to translate genetic studies of psychiatric disorders into clinically actionable information, which could transform diagnostics and even one day lead to novel (and potentially presymptomatic) therapeutic interventions. Today, although there are hundreds of significant loci associated with psychiatric disorders, resolving the target gene(s) and pathway(s) impacted by each is a major challenge. Link: ./index.php?lvl=notice_display&id=28524 [artículo] Using stem cell models to explore the genetics underlying psychiatric disorders : linking risk variants, genes, and biology in brain disease [texto impreso] / Kristen J. Brennand, Autor . - 2022 . - pp. 322-328. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 322-328 Palabras clave: Genética - Genómica, Biología, Esquizofrenia Resumen: There is an urgent and unmet need to advance our ability to translate genetic studies of psychiatric disorders into clinically actionable information, which could transform diagnostics and even one day lead to novel (and potentially presymptomatic) therapeutic interventions. Today, although there are hundreds of significant loci associated with psychiatric disorders, resolving the target gene(s) and pathway(s) impacted by each is a major challenge. Link: ./index.php?lvl=notice_display&id=28524

The emergence of psychiatry / Kenneth S. Kendler en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 329-335 Título : The emergence of psychiatry : 1650–1850 Tipo de documento: texto impreso Autores: Kenneth S. Kendler, Autor ; Kathryn Tabb, Autor ; John Wright, Autor Fecha de publicación: 2022 Artículo en la página: pp. 329-335 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Historia de la psiquiatría, Filosofía Resumen: Western psychiatry emerged as a medical specialty caring for the mentally ill over the course of the late 18th and early 19th centuries. This emergence was a contingent process, dependent on the co-occurrence of three historical developments that together shaped the young discipline. The first was the rise of the mind as an entity with numerous active faculties in the conceptual space between the body and the Christian soul. Link: ./index.php?lvl=notice_display&id=28525 [artículo] The emergence of psychiatry : 1650–1850 [texto impreso] / Kenneth S. Kendler, Autor ; Kathryn Tabb, Autor ; John Wright, Autor . - 2022 . - pp. 329-335. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 329-335 Palabras clave: Historia de la psiquiatría, Filosofía Resumen: Western psychiatry emerged as a medical specialty caring for the mentally ill over the course of the late 18th and early 19th centuries. This emergence was a contingent process, dependent on the co-occurrence of three historical developments that together shaped the young discipline. The first was the rise of the mind as an entity with numerous active faculties in the conceptual space between the body and the Christian soul. Link: ./index.php?lvl=notice_display&id=28525

Neurobiological correlates of change in adaptive behavior in autism / Charlotte M. Pretzsch en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 336-349 Título : Neurobiological correlates of change in adaptive behavior in autism Tipo de documento: texto impreso Autores: Charlotte M. Pretzsch, Autor ; Tim Schäfer, Autor ; Michael V. Lombardo, Autor Fecha de publicación: 2022 Artículo en la página: pp. 336-349 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos del neurodesarrollo, Trastorno del espectro autista, Neuroanatomía, Genética - Genómica, Neuroimagen, Marcadores biológicos. Resumen: Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition that is associated with significant difficulties in adaptive behavior and variation in clinical outcomes across the life span. Some individuals with ASD improve, whereas others may not change significantly, or regress. Hence, the development of “personalized medicine” approaches is essential. Link: ./index.php?lvl=notice_display&id=28526 [artículo] Neurobiological correlates of change in adaptive behavior in autism [texto impreso] / Charlotte M. Pretzsch, Autor ; Tim Schäfer, Autor ; Michael V. Lombardo, Autor . - 2022 . - pp. 336-349. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 336-349 Palabras clave: Trastornos del neurodesarrollo, Trastorno del espectro autista, Neuroanatomía, Genética - Genómica, Neuroimagen, Marcadores biológicos. Resumen: Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition that is associated with significant difficulties in adaptive behavior and variation in clinical outcomes across the life span. Some individuals with ASD improve, whereas others may not change significantly, or regress. Hence, the development of “personalized medicine” approaches is essential. Link: ./index.php?lvl=notice_display&id=28526

Longitudinal changes in structural connectivity in young people at high genetic risk for bipolar disorder / Gloria Roberts en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 350-361 Título : Longitudinal changes in structural connectivity in young people at high genetic risk for bipolar disorder Tipo de documento: texto impreso Autores: Gloria Roberts, Autor ; Alistair Perry, Autor ; Kate Ridgway, Autor Fecha de publicación: 2022 Artículo en la página: pp. 350-361 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos bipolares y relacionados, Longitudinales, Riesgo genético, Conectividad estructural, Desarrollo Resumen: Recent studies of patients with bipolar disorder or at high genetic risk reveal structural dysconnections among key brain networks supporting cognitive and affective processes. Understanding the longitudinal trajectories of these networks across the peak age range of bipolar disorder onset could inform mechanisms of illness onset or resilience. Link: ./index.php?lvl=notice_display&id=28527 [artículo] Longitudinal changes in structural connectivity in young people at high genetic risk for bipolar disorder [texto impreso] / Gloria Roberts, Autor ; Alistair Perry, Autor ; Kate Ridgway, Autor . - 2022 . - pp. 350-361. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 350-361 Palabras clave: Trastornos bipolares y relacionados, Longitudinales, Riesgo genético, Conectividad estructural, Desarrollo Resumen: Recent studies of patients with bipolar disorder or at high genetic risk reveal structural dysconnections among key brain networks supporting cognitive and affective processes. Understanding the longitudinal trajectories of these networks across the peak age range of bipolar disorder onset could inform mechanisms of illness onset or resilience. Link: ./index.php?lvl=notice_display&id=28527

Long term cannabis use and cognitive reserves and hippocampal volume in midlife / Madeline H. Meier en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 362-374 Título : Long term cannabis use and cognitive reserves and hippocampal volume in midlife Tipo de documento: texto impreso Autores: Madeline H. Meier, Autor ; Avshalom Caspi, Autor ; Annchen R. Knodt, Autor Fecha de publicación: 2022 Artículo en la página: pp. 362-374 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Cannabis, Trastornos adictivos y relacionados con sustancias, Cognición - Aprendizaje - Memoria, Neuroimagen Resumen: Cannabis use is increasing among midlife and older adults. This study tested the hypotheses that long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife, which is important because midlife cognitive deficits and smaller hippocampal volume are risk factors for dementia. Link: ./index.php?lvl=notice_display&id=28528 [artículo] Long term cannabis use and cognitive reserves and hippocampal volume in midlife [texto impreso] / Madeline H. Meier, Autor ; Avshalom Caspi, Autor ; Annchen R. Knodt, Autor . - 2022 . - pp. 362-374. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 362-374 Palabras clave: Cannabis, Trastornos adictivos y relacionados con sustancias, Cognición - Aprendizaje - Memoria, Neuroimagen Resumen: Cannabis use is increasing among midlife and older adults. This study tested the hypotheses that long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife, which is important because midlife cognitive deficits and smaller hippocampal volume are risk factors for dementia. Link: ./index.php?lvl=notice_display&id=28528

Cell type specific impact of glucocorticoid receptor activation on the developing brain / Cristiana Cruceanu en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 375-387 Título : Cell type specific impact of glucocorticoid receptor activation on the developing brain : a cerebral organoid study Tipo de documento: texto impreso Autores: Cristiana Cruceanu, Autor ; Leander Dony, Autor ; Anthi C. Krontira, Autor Fecha de publicación: 2022 Artículo en la página: pp. 375-387 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Receptor de glucocorticoides, Cerebro, Biología, Psiquiatría infantil - adolescente, Desarrollo, Trastornos del neurodesarrollo, Investigación Traslacional, Estrés, Problemas Pre - Peri - Postnatales. Resumen: A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing many health outcomes. In utero, glucocorticoids have been linked to brain-related negative outcomes, with unclear underlying mechanisms, especially regarding cell-type-specific effects. Link: ./index.php?lvl=notice_display&id=28529 [artículo] Cell type specific impact of glucocorticoid receptor activation on the developing brain : a cerebral organoid study [texto impreso] / Cristiana Cruceanu, Autor ; Leander Dony, Autor ; Anthi C. Krontira, Autor . - 2022 . - pp. 375-387. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 5 (Mayo) . - pp. 375-387 Palabras clave: Receptor de glucocorticoides, Cerebro, Biología, Psiquiatría infantil - adolescente, Desarrollo, Trastornos del neurodesarrollo, Investigación Traslacional, Estrés, Problemas Pre - Peri - Postnatales. Resumen: A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing many health outcomes. In utero, glucocorticoids have been linked to brain-related negative outcomes, with unclear underlying mechanisms, especially regarding cell-type-specific effects. Link: ./index.php?lvl=notice_display&id=28529