Artículos

Toward a better understanding of the mechanisms and pathophysiology of anhedonia / Diego A. Pizzagalli en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No.7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 458–469 Título : Toward a better understanding of the mechanisms and pathophysiology of anhedonia : are we ready for translation? Tipo de documento: texto impreso Autores: Diego A. Pizzagalli, Autor Fecha de publicación: 2022 Artículo en la página: pp. 458–469 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos depresivos, Trastorno depresivo mayor, Técnicas de Imágenes Cerebrales, Neurociencia Cognitiva, Neurocircuitos Resumen: Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a formidable treatment challenge across neuropsychiatric disorders. In major depressive disorder, anhedonia has been linked to poor disease course, worse response to psychological, pharmacological, and neurostimulation treatments, and increased suicide risk. Link: ./index.php?lvl=notice_display&id=28580 [artículo] Toward a better understanding of the mechanisms and pathophysiology of anhedonia : are we ready for translation? [texto impreso] / Diego A. Pizzagalli, Autor . - 2022 . - pp. 458–469. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 458–469 Palabras clave: Trastornos depresivos, Trastorno depresivo mayor, Técnicas de Imágenes Cerebrales, Neurociencia Cognitiva, Neurocircuitos Resumen: Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a formidable treatment challenge across neuropsychiatric disorders. In major depressive disorder, anhedonia has been linked to poor disease course, worse response to psychological, pharmacological, and neurostimulation treatments, and increased suicide risk. Link: ./index.php?lvl=notice_display&id=28580

Longitudinal trajectory of the link between ventral striatum and depression in adolescence / Pedro Mario Pan en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No.7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 470-481 Título : Longitudinal trajectory of the link between ventral striatum and depression in adolescence Tipo de documento: texto impreso Autores: Pedro Mario Pan, Autor ; João Ricardo Sato, Autor ; Marie-Laure Paillére Martinot, Autor Fecha de publicación: 2022 Artículo en la página: pp. 470-481 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos depresivos, Neuroimagen, Grupos, Desarrollo. Resumen: Research in adolescent depression has found aberrant intrinsic functional connectivity (iFC) among the ventral striatum (VS) and several brain regions implicated in reward processing. The present study probes this question by taking advantage of the availability of data from a large youth cohort, the IMAGEN Consortium. Link: ./index.php?lvl=notice_display&id=28581 [artículo] Longitudinal trajectory of the link between ventral striatum and depression in adolescence [texto impreso] / Pedro Mario Pan, Autor ; João Ricardo Sato, Autor ; Marie-Laure Paillére Martinot, Autor . - 2022 . - pp. 470-481. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 470-481 Palabras clave: Trastornos depresivos, Neuroimagen, Grupos, Desarrollo. Resumen: Research in adolescent depression has found aberrant intrinsic functional connectivity (iFC) among the ventral striatum (VS) and several brain regions implicated in reward processing. The present study probes this question by taking advantage of the availability of data from a large youth cohort, the IMAGEN Consortium. Link: ./index.php?lvl=notice_display&id=28581

Digital intervention for cognitive deficits in major depression / Richard S.E. Keefe en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No.7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 482-489 Título : Digital intervention for cognitive deficits in major depression : a randomized controlled trial to assess efficacy and safety in adults Tipo de documento: texto impreso Autores: Richard S.E. Keefe, Autor ; Elena Cañadas, Autor ; Deborah Farlow, Autor Fecha de publicación: 2022 Artículo en la página: pp. 482-489 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno depresivo mayor, Deterioro cognitivo, Intervención digital Resumen: The authors evaluated AKL-T03, an investigational digital intervention delivered through a video game–based interface, designed to target the fronto-parietal network to enhance functional domains for attentional control. AKL-T03 was tested in adult patients with major depressive disorder and a demonstrated cognitive impairment at baseline. Link: ./index.php?lvl=notice_display&id=28582 [artículo] Digital intervention for cognitive deficits in major depression : a randomized controlled trial to assess efficacy and safety in adults [texto impreso] / Richard S.E. Keefe, Autor ; Elena Cañadas, Autor ; Deborah Farlow, Autor . - 2022 . - pp. 482-489. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 482-489 Palabras clave: Trastorno depresivo mayor, Deterioro cognitivo, Intervención digital Resumen: The authors evaluated AKL-T03, an investigational digital intervention delivered through a video game–based interface, designed to target the fronto-parietal network to enhance functional domains for attentional control. AKL-T03 was tested in adult patients with major depressive disorder and a demonstrated cognitive impairment at baseline. Link: ./index.php?lvl=notice_display&id=28582

Effect of axs-05 (dextromethorphan-bupropion) in major depressive disorder / Herriot Tabuteau en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No.7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 490-499 Título : Effect of axs-05 (dextromethorphan-bupropion) in major depressive disorder : a randomized double-blind controlled trial Tipo de documento: texto impreso Autores: Herriot Tabuteau, Autor ; Amanda Jones, Autor ; Ashley Anderson, Autor Fecha de publicación: 2022 Artículo en la página: pp. 490-499 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno depresivo mayor, Dextrometorfano, Bupropión Resumen: Altered glutamatergic neurotransmission is implicated in the pathogenesis of major depressive disorder. AXS-05 (dextromethorphan-bupropion) is an oral NMDA receptor antagonist and sigma-1 receptor agonist, which utilizes inhibition of CYP2D6 to increase its bioavailability. This phase 2 trial assessed the efficacy and safety of dextromethorphan-bupropion in the treatment of major depressive disorder. Link: ./index.php?lvl=notice_display&id=28583 [artículo] Effect of axs-05 (dextromethorphan-bupropion) in major depressive disorder : a randomized double-blind controlled trial [texto impreso] / Herriot Tabuteau, Autor ; Amanda Jones, Autor ; Ashley Anderson, Autor . - 2022 . - pp. 490-499. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 490-499 Palabras clave: Trastorno depresivo mayor, Dextrometorfano, Bupropión Resumen: Altered glutamatergic neurotransmission is implicated in the pathogenesis of major depressive disorder. AXS-05 (dextromethorphan-bupropion) is an oral NMDA receptor antagonist and sigma-1 receptor agonist, which utilizes inhibition of CYP2D6 to increase its bioavailability. This phase 2 trial assessed the efficacy and safety of dextromethorphan-bupropion in the treatment of major depressive disorder. Link: ./index.php?lvl=notice_display&id=28583

Predictive value of acute neuroplastic response to rtms in treatment outcome in depression / Ruiyang Ge en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No.7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 500-508 Título : Predictive value of acute neuroplastic response to rtms in treatment outcome in depression : a concurrent tms-fmri trial Tipo de documento: texto impreso Autores: Ruiyang Ge, Autor ; Afifa Humaira, Autor ; Elizabeth Gregory, Autor Fecha de publicación: 2022 Artículo en la página: pp. 500-508 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos depresivos, Neuroestimulación, TMS, Técnicas de imágenes cerebrales Resumen: The study objective was to investigate the predictive value of functional connectivity changes induced by acute repetitive transcranial magnetic stimulation (rTMS) for clinical response in treatment-resistant depression. Link: ./index.php?lvl=notice_display&id=28584 [artículo] Predictive value of acute neuroplastic response to rtms in treatment outcome in depression : a concurrent tms-fmri trial [texto impreso] / Ruiyang Ge, Autor ; Afifa Humaira, Autor ; Elizabeth Gregory, Autor . - 2022 . - pp. 500-508. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 500-508 Palabras clave: Trastornos depresivos, Neuroestimulación, TMS, Técnicas de imágenes cerebrales Resumen: The study objective was to investigate the predictive value of functional connectivity changes induced by acute repetitive transcranial magnetic stimulation (rTMS) for clinical response in treatment-resistant depression. Link: ./index.php?lvl=notice_display&id=28584

No association between amygdala responses to negative faces and depressive symptoms / Sandra Tamm en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No.7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 509-513 Título : No association between amygdala responses to negative faces and depressive symptoms : cross-sectional data from 28,638 individuals in the uk biobank cohort Tipo de documento: texto impreso Autores: Sandra Tamm, Autor ; Catherine J. Harmer, Autor ; Julian Schiel, Autor Fecha de publicación: 2022 Artículo en la página: pp. 509-513 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos Depresivos, Neuroimagen Resumen: Neurocognitive models of depression emphasize the role of the amygdala in dysfunctional emotional processing (1, 2). Specifically, increased amygdala responsiveness to negative stimuli is posited as a mechanism underlying the aberrant low-level emotional processing in depressed individuals, manifesting as a negativity bias in the perception and recognition of emotional stimuli (3). Link: ./index.php?lvl=notice_display&id=28585 [artículo] No association between amygdala responses to negative faces and depressive symptoms : cross-sectional data from 28,638 individuals in the uk biobank cohort [texto impreso] / Sandra Tamm, Autor ; Catherine J. Harmer, Autor ; Julian Schiel, Autor . - 2022 . - pp. 509-513. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No.7 (Julio) . - pp. 509-513 Palabras clave: Trastornos Depresivos, Neuroimagen Resumen: Neurocognitive models of depression emphasize the role of the amygdala in dysfunctional emotional processing (1, 2). Specifically, increased amygdala responsiveness to negative stimuli is posited as a mechanism underlying the aberrant low-level emotional processing in depressed individuals, manifesting as a negativity bias in the perception and recognition of emotional stimuli (3). Link: ./index.php?lvl=notice_display&id=28585