Artículos

Muscarinic acetylcholine receptor agonists as novel treatments for schizophrenia / Steven M. Paul en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 9 (Septiembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 611-627 Título : Muscarinic acetylcholine receptor agonists as novel treatments for schizophrenia Tipo de documento: texto impreso Autores: Steven M. Paul, Autor ; Samantha E. Yohn, Autor ; Michael Popiolek, Autor Fecha de publicación: 2022 Artículo en la página: pp. 611-627 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Espectro de esquizofrenia - otros trastornos psicóticos, Antipsicóticos, Receptores muscarínicos, Síntomas positivos, negativos y Cognitivos Resumen: Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across the entire spectrum of core symptoms as well as their often burdensome side-effect profiles and poor tolerability. An unmet need remains for novel, mechanistically unique, and better tolerated therapeutic agents for treating schizophrenia, especially those that treat not only positive symptoms but also the negative and cognitive symptoms of the disease. Link: ./index.php?lvl=notice_display&id=29389 [artículo] Muscarinic acetylcholine receptor agonists as novel treatments for schizophrenia [texto impreso] / Steven M. Paul, Autor ; Samantha E. Yohn, Autor ; Michael Popiolek, Autor . - 2022 . - pp. 611-627. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 611-627 Palabras clave: Espectro de esquizofrenia - otros trastornos psicóticos, Antipsicóticos, Receptores muscarínicos, Síntomas positivos, negativos y Cognitivos Resumen: Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across the entire spectrum of core symptoms as well as their often burdensome side-effect profiles and poor tolerability. An unmet need remains for novel, mechanistically unique, and better tolerated therapeutic agents for treating schizophrenia, especially those that treat not only positive symptoms but also the negative and cognitive symptoms of the disease. Link: ./index.php?lvl=notice_display&id=29389

Developmental pathways and clinical outcomes of early childhood psychotic experiences in preadolescent children at familial high risk of schizophrenia or bipolar disorder / Maja Gregersen en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 9 (Septiembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 628-639 Título : Developmental pathways and clinical outcomes of early childhood psychotic experiences in preadolescent children at familial high risk of schizophrenia or bipolar disorder : a prospective, longitudinal cohort study - the danish high risk and resilience study, via 11 Tipo de documento: texto impreso Autores: Maja Gregersen, Autor ; Jens Richardt Møllegaard Jepsen, Autor ; Sinnika Birkehøj Rohd, Autor Fecha de publicación: 2022 Artículo en la página: pp. 628-639 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Espectro de esquizofrenia, Trastornos psicóticos, Trastornos bipolares y relacionados, Psiquiatría infantil / adolescente Resumen: Psychotic experiences are common in children and adolescents and are associated with concurrent and subsequent psychopathology. Most findings originate from general population studies, whereas little is known of the clinical outcomes of psychotic experiences in children and adolescents at familial high risk of psychosis. Link: ./index.php?lvl=notice_display&id=29390 [artículo] Developmental pathways and clinical outcomes of early childhood psychotic experiences in preadolescent children at familial high risk of schizophrenia or bipolar disorder : a prospective, longitudinal cohort study - the danish high risk and resilience study, via 11 [texto impreso] / Maja Gregersen, Autor ; Jens Richardt Møllegaard Jepsen, Autor ; Sinnika Birkehøj Rohd, Autor . - 2022 . - pp. 628-639. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 628-639 Palabras clave: Espectro de esquizofrenia, Trastornos psicóticos, Trastornos bipolares y relacionados, Psiquiatría infantil / adolescente Resumen: Psychotic experiences are common in children and adolescents and are associated with concurrent and subsequent psychopathology. Most findings originate from general population studies, whereas little is known of the clinical outcomes of psychotic experiences in children and adolescents at familial high risk of psychosis. Link: ./index.php?lvl=notice_display&id=29390

An extended swedish adoption study of anxiety disorder and its cross generational familial relationship with major depression / Kenneth S. Kendler en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 9 (Septiembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 640-649 Título : An extended swedish adoption study of anxiety disorder and its cross generational familial relationship with major depression Tipo de documento: texto impreso Autores: Kenneth S. Kendler, Autor ; Linda Abrahamsson, Autor ; Henrik Ohlsson, Autor Fecha de publicación: 2022 Artículo en la página: pp. 640-649 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos de ansiedad, Trastornos depresivos, Trastorno depresivo mayor, Genética / Genómica Resumen: To clarify, using an extended adoption design, the sources of parent-offspring transmission for anxiety disorder (AD) and its major subforms and their familial cross-generational relationship with major depression (MD). Link: ./index.php?lvl=notice_display&id=29391 [artículo] An extended swedish adoption study of anxiety disorder and its cross generational familial relationship with major depression [texto impreso] / Kenneth S. Kendler, Autor ; Linda Abrahamsson, Autor ; Henrik Ohlsson, Autor . - 2022 . - pp. 640-649. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 640-649 Palabras clave: Trastornos de ansiedad, Trastornos depresivos, Trastorno depresivo mayor, Genética / Genómica Resumen: To clarify, using an extended adoption design, the sources of parent-offspring transmission for anxiety disorder (AD) and its major subforms and their familial cross-generational relationship with major depression (MD). Link: ./index.php?lvl=notice_display&id=29391

Schizophrenia imaging signatures and their associations with cognition, psychopathology, and genetics in the general population / Ganesh B. Chand en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 9 (Septiembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 650-660 Título : Schizophrenia imaging signatures and their associations with cognition, psychopathology, and genetics in the general population Tipo de documento: texto impreso Autores: Ganesh B. Chand, Autor ; Pankhuri Singhal, Autor Fecha de publicación: 2022 Artículo en la página: pp. 650-660 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Aprendizaje automático, Neuroanatomía, Neuroimagen, Espectro de esquizofrenia, Trastornos psicóticos, Genética, Genómica, Puntuaciones de riesgo poligénico Resumen: The prevalence and significance of schizophrenia-related phenotypes at the population level is debated in the literature. Here, the authors assessed whether two recently reported neuroanatomical signatures of schizophrenia—signature 1, with widespread reduction of gray matter volume, and signature 2, with increased striatal volume—could be replicated in an independent schizophrenia sample,... Link: ./index.php?lvl=notice_display&id=29392 [artículo] Schizophrenia imaging signatures and their associations with cognition, psychopathology, and genetics in the general population [texto impreso] / Ganesh B. Chand, Autor ; Pankhuri Singhal, Autor . - 2022 . - pp. 650-660. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 650-660 Palabras clave: Aprendizaje automático, Neuroanatomía, Neuroimagen, Espectro de esquizofrenia, Trastornos psicóticos, Genética, Genómica, Puntuaciones de riesgo poligénico Resumen: The prevalence and significance of schizophrenia-related phenotypes at the population level is debated in the literature. Here, the authors assessed whether two recently reported neuroanatomical signatures of schizophrenia—signature 1, with widespread reduction of gray matter volume, and signature 2, with increased striatal volume—could be replicated in an independent schizophrenia sample,... Link: ./index.php?lvl=notice_display&id=29392

Persistent dissociation and its neural correlates in predicting outcomes after trauma exposure / Lauren A.M. Lebois en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 9 (Septiembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 661-672 Título : Persistent dissociation and its neural correlates in predicting outcomes after trauma exposure Tipo de documento: texto impreso Autores: Lauren A.M. Lebois, Autor ; Nathaniel G. Harnett, Autor ; Sanne J.H. van Rooij, Autor Fecha de publicación: 2022 Artículo en la página: pp. 661-672 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos disociativos, Despersonalización - Desrealización, Marcadores biológicos, Neuroimagen, Trastorno de estrés postraumático, (TEPT) Resumen: Dissociation, a disruption or discontinuity in psychological functioning, is often linked with worse psychiatric symptoms; however, the prognostic value of dissociation after trauma is inconsistent. Determining whether trauma-related dissociation is uniquely predictive of later outcomes would enable early identification of at-risk trauma populations. Link: ./index.php?lvl=notice_display&id=29393 [artículo] Persistent dissociation and its neural correlates in predicting outcomes after trauma exposure [texto impreso] / Lauren A.M. Lebois, Autor ; Nathaniel G. Harnett, Autor ; Sanne J.H. van Rooij, Autor . - 2022 . - pp. 661-672. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 661-672 Palabras clave: Trastornos disociativos, Despersonalización - Desrealización, Marcadores biológicos, Neuroimagen, Trastorno de estrés postraumático, (TEPT) Resumen: Dissociation, a disruption or discontinuity in psychological functioning, is often linked with worse psychiatric symptoms; however, the prognostic value of dissociation after trauma is inconsistent. Determining whether trauma-related dissociation is uniquely predictive of later outcomes would enable early identification of at-risk trauma populations. Link: ./index.php?lvl=notice_display&id=29393

Decoding shared versus divergent transcriptomic signatures across cortico amygdala circuitry in ptsd and depressive disorders / Andrew E. Jaffe en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 9 (Septiembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 673-686 Título : Decoding shared versus divergent transcriptomic signatures across cortico amygdala circuitry in ptsd and depressive disorders Tipo de documento: texto impreso Autores: Andrew E. Jaffe, Autor ; Tao Ran, Autor ; Stephanie C. Page, Autor Fecha de publicación: 2022 Artículo en la página: pp. 673-686 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno de estrés postraumático (TEPT), Trastornos depresivos, Trastorno depresivo mayor, Tejido post mortem humano, Secuenciación de ARN Resumen: Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The overlap in symptoms is hypothesized to stem from partially shared genetics and underlying neurobiological mechanisms. To delineate conservation between transcriptional patterns across PTSD and MDD, the authors examined gene expression in the human cortex and amygdala in these disorders. Link: ./index.php?lvl=notice_display&id=29394 [artículo] Decoding shared versus divergent transcriptomic signatures across cortico amygdala circuitry in ptsd and depressive disorders [texto impreso] / Andrew E. Jaffe, Autor ; Tao Ran, Autor ; Stephanie C. Page, Autor . - 2022 . - pp. 673-686. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 9 (Septiembre) . - pp. 673-686 Palabras clave: Trastorno de estrés postraumático (TEPT), Trastornos depresivos, Trastorno depresivo mayor, Tejido post mortem humano, Secuenciación de ARN Resumen: Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The overlap in symptoms is hypothesized to stem from partially shared genetics and underlying neurobiological mechanisms. To delineate conservation between transcriptional patterns across PTSD and MDD, the authors examined gene expression in the human cortex and amygdala in these disorders. Link: ./index.php?lvl=notice_display&id=29394