Genetic heterogeneity across dimensions of alcohol use behaviors / Jeanne Savage en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 11 (Noviembre) . - pp. 1006-1017 Título : Genetic heterogeneity across dimensions of alcohol use behaviors Tipo de documento: texto impreso Autores: Jeanne Savage, Autor ; Peter B. Barr, Autor ; Tanya Phung, Autor Fecha de publicación: 2024 Artículo en la página: pp. 1006-1017 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Alcohol, GWAS, Genética - Genómica, Modelado de ecuaciones estructurales genómicas, Trastornos adictivos y relacionados con sustancias. Resumen: Increasingly large samples in genome-wide association studies (GWASs) for alcohol use behaviors (AUBs) have led to an influx of implicated genes, yet the clinical and functional understanding of these associations remains low, in part because most GWASs do not account for the complex and varied manifestations of AUBs. Link: ./index.php?lvl=notice_display&id=31475 [artículo] Genetic heterogeneity across dimensions of alcohol use behaviors [texto impreso] / Jeanne Savage, Autor ; Peter B. Barr, Autor ; Tanya Phung, Autor . - 2024 . - pp. 1006-1017. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 11 (Noviembre) . - pp. 1006-1017 Palabras clave: Alcohol, GWAS, Genética - Genómica, Modelado de ecuaciones estructurales genómicas, Trastornos adictivos y relacionados con sustancias. Resumen: Increasingly large samples in genome-wide association studies (GWASs) for alcohol use behaviors (AUBs) have led to an influx of implicated genes, yet the clinical and functional understanding of these associations remains low, in part because most GWASs do not account for the complex and varied manifestations of AUBs. Link: ./index.php?lvl=notice_display&id=31475

A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms / Jeanne Savage en Journal of the American Academy of Child & Adolescent Psychiatry, Año 2015 - Vol.54 - No.5 (Mayo)

Público ISBD [artículo]  inJournal of the American Academy of Child & Adolescent Psychiatry > Año 2015 - Vol.54 - No.5 (Mayo) . - pp. 377–384 Título : A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms Tipo de documento: texto impreso Autores: Jeanne Savage, Autor ; Brad Verhulst, Autor ; William E. Copeland, Autor Fecha de publicación: 2020 Artículo en la página: pp. 377–384 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Irritabilidad, Ansiedad, Depresión, Genética, Gemelos Resumen: Little is known about the longitudinal genetic and environmental association between juvenile irritability and symptoms of anxiety and depression. This study’s goal was to assess the relationship between these constructs across a critical developmental period spanning childhood to young adulthood. Link: ./index.php?lvl=notice_display&id=22526 [artículo] A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms [texto impreso] / Jeanne Savage, Autor ; Brad Verhulst, Autor ; William E. Copeland, Autor . - 2020 . - pp. 377–384. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2015 - Vol.54 - No.5 (Mayo) . - pp. 377–384 Palabras clave: Irritabilidad, Ansiedad, Depresión, Genética, Gemelos Resumen: Little is known about the longitudinal genetic and environmental association between juvenile irritability and symptoms of anxiety and depression. This study’s goal was to assess the relationship between these constructs across a critical developmental period spanning childhood to young adulthood. Link: ./index.php?lvl=notice_display&id=22526

Item level genome wide association study of the alcohol use disorders identification test in three population based cohorts / Travis T. Mallard en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 1 (Enero)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 1 (Enero) . - pp. 58-70 Título : Item level genome wide association study of the alcohol use disorders identification test in three population based cohorts Tipo de documento: texto impreso Autores: Travis T. Mallard, Autor ; Jeanne Savage, Autor ; Emma C. Johnson, Autor Fecha de publicación: 2022 Artículo en la página: pp. 58-70 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: GWAS, Trastornos adictivos relacionados con sustancias, Alcohol, Modelado de ecuaciones estructurales genómicas, Consumo de alcohol, ALSPAC Resumen: Genome-wide association studies (GWASs) of the Alcohol Use Disorders Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated novel loci for alcohol consumption and misuse. However, these studies also revealed that GWASs can be influenced by numerous biases (e.g., measurement error, selection bias), which may have led to inconsistent genetic correlations between alcohol involvement and AUD, as well as paradoxically negative genetic correlations between alcohol involvement and psychiatric disorders and/or medical conditions. Link: ./index.php?lvl=notice_display&id=28326 [artículo] Item level genome wide association study of the alcohol use disorders identification test in three population based cohorts [texto impreso] / Travis T. Mallard, Autor ; Jeanne Savage, Autor ; Emma C. Johnson, Autor . - 2022 . - pp. 58-70. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 1 (Enero) . - pp. 58-70 Palabras clave: GWAS, Trastornos adictivos relacionados con sustancias, Alcohol, Modelado de ecuaciones estructurales genómicas, Consumo de alcohol, ALSPAC Resumen: Genome-wide association studies (GWASs) of the Alcohol Use Disorders Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated novel loci for alcohol consumption and misuse. However, these studies also revealed that GWASs can be influenced by numerous biases (e.g., measurement error, selection bias), which may have led to inconsistent genetic correlations between alcohol involvement and AUD, as well as paradoxically negative genetic correlations between alcohol involvement and psychiatric disorders and/or medical conditions. Link: ./index.php?lvl=notice_display&id=28326

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