Artículos

Optimizing limbic selective d2/d3 receptor occupancy by risperidone: a [123i]-epidepride spet study / Rodrigo A. Bressan en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 5-14 Título : Optimizing limbic selective d2/d3 receptor occupancy by risperidone: a [123i]-epidepride spet study Tipo de documento: texto impreso Autores: Rodrigo A. Bressan, Autor ; Kjell Erlandsson, Autor ; Hugh M. Jones, Autor Fecha de publicación: 2023 Artículo en la página: pp. 5-14 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Sistema Límbico, Sistema límbico, Pirrolidinas, Receptores de dopamina D2, Risperidona, Esquizofrenia. Resumen: Selective action at limbic cortical dopamine D2-like receptors is a putative mechanism of atypical antipsychotic efficacy with few extrapyramidal side effects. Although risperidone is an atypical antipsychotic with high affinity for D2 receptors, low-dose risperidone treatment is effective without inducing extrapyramidal symptoms. Link: ./index.php?lvl=notice_display&id=31038 [artículo] Optimizing limbic selective d2/d3 receptor occupancy by risperidone: a [123i]-epidepride spet study [texto impreso] / Rodrigo A. Bressan, Autor ; Kjell Erlandsson, Autor ; Hugh M. Jones, Autor . - 2023 . - pp. 5-14. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 5-14 Palabras clave: Antipsicóticos, Sistema Límbico, Sistema límbico, Pirrolidinas, Receptores de dopamina D2, Risperidona, Esquizofrenia. Resumen: Selective action at limbic cortical dopamine D2-like receptors is a putative mechanism of atypical antipsychotic efficacy with few extrapyramidal side effects. Although risperidone is an atypical antipsychotic with high affinity for D2 receptors, low-dose risperidone treatment is effective without inducing extrapyramidal symptoms. Link: ./index.php?lvl=notice_display&id=31038

Quetiapine treatment in patients with posttraumatic stress disorder: an open trial of adjunctive therapy / Mark B. Hamner en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 15-20 Título : Quetiapine treatment in patients with posttraumatic stress disorder: an open trial of adjunctive therapy Tipo de documento: texto impreso Autores: Mark B. Hamner, Autor ; Sarah E. Deitsch, Autor ; Peter S. Brodrick, Autor Fecha de publicación: 2023 Artículo en la página: pp. 15-20 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Dibenzotiacepinas, Fumarato de quetiapina, Trastornos de estrés postraumático, Trastornos relacionados con sustancias. Resumen: In this 6-week, open-label trial, combat veterans meeting DSM-IV criteria for posttraumatic stress disorder (PTSD) were treated with the atypical antipsychotic quetiapine. The starting dose was 25 mg at bedtime with subsequent titration based on tolerability and clinical response. Primary outcome was measured using the Clinician Administered PTSD Scale (CAPS). Link: ./index.php?lvl=notice_display&id=31039 [artículo] Quetiapine treatment in patients with posttraumatic stress disorder: an open trial of adjunctive therapy [texto impreso] / Mark B. Hamner, Autor ; Sarah E. Deitsch, Autor ; Peter S. Brodrick, Autor . - 2023 . - pp. 15-20. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 15-20 Palabras clave: Antipsicóticos, Dibenzotiacepinas, Fumarato de quetiapina, Trastornos de estrés postraumático, Trastornos relacionados con sustancias. Resumen: In this 6-week, open-label trial, combat veterans meeting DSM-IV criteria for posttraumatic stress disorder (PTSD) were treated with the atypical antipsychotic quetiapine. The starting dose was 25 mg at bedtime with subsequent titration based on tolerability and clinical response. Primary outcome was measured using the Clinician Administered PTSD Scale (CAPS). Link: ./index.php?lvl=notice_display&id=31039

Single-blind comparison of venlafaxine and nortriptyline in elderly major depression / Cristóbal Gastó en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 21-26 Título : Single-blind comparison of venlafaxine and nortriptyline in elderly major depression Tipo de documento: texto impreso Autores: Cristóbal Gastó, Autor ; Víctor Navarro, Autor ; Teodoro Marcos, Autor Fecha de publicación: 2023 Artículo en la página: pp. 21-26 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos tricíclicos, Ciclohexanoles, Trastorno depresivo mayor, Electrocardiografía, Nortriptilina. Resumen: The objective of this single-blind study was to compare the efficacy and safety of venlafaxine extended-release and nortriptyline in elderly patients with moderate to severe major depression. In- and out-patients (N=68) with unipolar major depression were randomized to receive 6-month treatment with either nortriptyline or venlafaxine. Link: ./index.php?lvl=notice_display&id=31040 [artículo] Single-blind comparison of venlafaxine and nortriptyline in elderly major depression [texto impreso] / Cristóbal Gastó, Autor ; Víctor Navarro, Autor ; Teodoro Marcos, Autor . - 2023 . - pp. 21-26. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 21-26 Palabras clave: Antidepresivos tricíclicos, Ciclohexanoles, Trastorno depresivo mayor, Electrocardiografía, Nortriptilina. Resumen: The objective of this single-blind study was to compare the efficacy and safety of venlafaxine extended-release and nortriptyline in elderly patients with moderate to severe major depression. In- and out-patients (N=68) with unipolar major depression were randomized to receive 6-month treatment with either nortriptyline or venlafaxine. Link: ./index.php?lvl=notice_display&id=31040

A prospective trial of bupropion sr augmentation of partial and non-responders to serotonergic antidepressants / Charles DeBattista en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 27-30 Título : A prospective trial of bupropion sr augmentation of partial and non-responders to serotonergic antidepressants Tipo de documento: texto impreso Autores: Charles DeBattista, Autor ; H. Brent Solvason, Autor ; Jennifer Poirier, Autor Fecha de publicación: 2023 Artículo en la página: pp. 27-30 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos de segunda generación, Bupropión, Trastorno depresivo, Resistencia al medicamento, Inhibidores selectivos de la recaptación de serotonina. Resumen: Many patients fail to achieve an adequate response to a given antidepressant trial. The best-studied augmentation agents, lithium and thyroid supplementation are less commonly used. Augmenting antidepressants with bupropion has become an increasingly common strategy in the treatment of resistant depression. Several case reports and 2 open label studies suggest efficacy of this strategy. Link: ./index.php?lvl=notice_display&id=31041 [artículo] A prospective trial of bupropion sr augmentation of partial and non-responders to serotonergic antidepressants [texto impreso] / Charles DeBattista, Autor ; H. Brent Solvason, Autor ; Jennifer Poirier, Autor . - 2023 . - pp. 27-30. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 27-30 Palabras clave: Antidepresivos de segunda generación, Bupropión, Trastorno depresivo, Resistencia al medicamento, Inhibidores selectivos de la recaptación de serotonina. Resumen: Many patients fail to achieve an adequate response to a given antidepressant trial. The best-studied augmentation agents, lithium and thyroid supplementation are less commonly used. Augmenting antidepressants with bupropion has become an increasingly common strategy in the treatment of resistant depression. Several case reports and 2 open label studies suggest efficacy of this strategy. Link: ./index.php?lvl=notice_display&id=31041

Cross-sectional database analysis of antidepressant prescribing in italy / Corrado Barbui en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 31-34 Título : Cross-sectional database analysis of antidepressant prescribing in italy Tipo de documento: texto impreso Autores: Corrado Barbui, Autor ; Elena Broglio, Autor ; Anna Costa Laia, Autor Fecha de publicación: 2023 Artículo en la página: pp. 31-34 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno Depresivo, Aspectos sexuales Resumen: Antidepressant drug trials have been criticised because they study atypical populations of depressive patients. The present cross-sectional database analysis was designed to define what constitutes a typical population of patients receiving antidepressants. From a database covering a population of 1,057,053 residents in Piedmont, Italy, and including all community (i.e. outside hospitals) prescriptions reimbursed by the National Health System, all prescriptions of antidepressant drugs dispensed during the first six months of 2000 were extracted. Link: ./index.php?lvl=notice_display&id=31042 [artículo] Cross-sectional database analysis of antidepressant prescribing in italy [texto impreso] / Corrado Barbui, Autor ; Elena Broglio, Autor ; Anna Costa Laia, Autor . - 2023 . - pp. 31-34. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 31-34 Palabras clave: Trastorno Depresivo, Aspectos sexuales Resumen: Antidepressant drug trials have been criticised because they study atypical populations of depressive patients. The present cross-sectional database analysis was designed to define what constitutes a typical population of patients receiving antidepressants. From a database covering a population of 1,057,053 residents in Piedmont, Italy, and including all community (i.e. outside hospitals) prescriptions reimbursed by the National Health System, all prescriptions of antidepressant drugs dispensed during the first six months of 2000 were extracted. Link: ./index.php?lvl=notice_display&id=31042

Improvement of sleep and pituitary-adrenal inhibition after subchronic intranasal vasopressin treatment in elderly humans / Boris Perras en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 35-44 Título : Improvement of sleep and pituitary-adrenal inhibition after subchronic intranasal vasopressin treatment in elderly humans Tipo de documento: texto impreso Autores: Boris Perras, Autor ; Ullrich Wagner, Autor ; Jan Born, Autor Fecha de publicación: 2023 Artículo en la página: pp. 35-44 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Arginina Vasopresina, Diuresis, Electroencefalografía, Frecuencia cardíaca, Hormona de crecimiento humano, Hidrocortisona, Efectos del sueño, Trastornos del sueño y la vigilia, Sueño. Resumen: Subchronic intranasal treatment with argininevasopressin (AVP) has been shown to exert a strong ameliorating effect on sleep and slow wave sleep (SWS) deficits in elderly. However, AVP is also a potent stimulus of the pituitary-adrenal stress system, which is usually inhibited during early, SWS-rich sleep. A disinhibition of pituitary-adrenal activity during sleep is correlated with aging and is considered a pathologic factor contributing to various age-related diseases. Link: ./index.php?lvl=notice_display&id=31043 [artículo] Improvement of sleep and pituitary-adrenal inhibition after subchronic intranasal vasopressin treatment in elderly humans [texto impreso] / Boris Perras, Autor ; Ullrich Wagner, Autor ; Jan Born, Autor . - 2023 . - pp. 35-44. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 35-44 Palabras clave: Arginina Vasopresina, Diuresis, Electroencefalografía, Frecuencia cardíaca, Hormona de crecimiento humano, Hidrocortisona, Efectos del sueño, Trastornos del sueño y la vigilia, Sueño. Resumen: Subchronic intranasal treatment with argininevasopressin (AVP) has been shown to exert a strong ameliorating effect on sleep and slow wave sleep (SWS) deficits in elderly. However, AVP is also a potent stimulus of the pituitary-adrenal stress system, which is usually inhibited during early, SWS-rich sleep. A disinhibition of pituitary-adrenal activity during sleep is correlated with aging and is considered a pathologic factor contributing to various age-related diseases. Link: ./index.php?lvl=notice_display&id=31043

The antidepressant efficacy of reboxetine in patients with severe depression / Stuart A. Montgomery en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 45-50 Título : The antidepressant efficacy of reboxetine in patients with severe depression Tipo de documento: texto impreso Autores: Stuart A. Montgomery, Autor ; James M. Ferguson, Autor ; Gerri E. Schwartz, Autor Fecha de publicación: 2023 Artículo en la página: pp. 45-50 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno depresivo mayor, Morfolinas - uso terapéutico Resumen: We examined the effectiveness of reboxetine, a norepinephrine reuptake inhibitor (NRI), compared with placebo for the treatment of patients with severe major depression (defined as a score on the 17-item Hamilton Rating Scale for Depression [HAM-D] ≥25). Link: ./index.php?lvl=notice_display&id=31044 [artículo] The antidepressant efficacy of reboxetine in patients with severe depression [texto impreso] / Stuart A. Montgomery, Autor ; James M. Ferguson, Autor ; Gerri E. Schwartz, Autor . - 2023 . - pp. 45-50. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 45-50 Palabras clave: Trastorno depresivo mayor, Morfolinas - uso terapéutico Resumen: We examined the effectiveness of reboxetine, a norepinephrine reuptake inhibitor (NRI), compared with placebo for the treatment of patients with severe major depression (defined as a score on the 17-item Hamilton Rating Scale for Depression [HAM-D] ≥25). Link: ./index.php?lvl=notice_display&id=31044

Anticipatory anxiety in moderately to highly-anxious oral surgery patients as a screening model for anxiolytics: evaluation of alprazolam / Daniel L. Wolf en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 51-57 Título : Anticipatory anxiety in moderately to highly-anxious oral surgery patients as a screening model for anxiolytics: evaluation of alprazolam Tipo de documento: texto impreso Autores: Daniel L. Wolf, Autor ; Paul J. Desjardins, Autor ; Peter M. Black, Autor Fecha de publicación: 2023 Artículo en la página: pp. 51-57 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Alprazolam, Ansiolíticos, Ansiedad, Presión arterial. Resumen: Alprazolam, a benzodiazepine anxiolytic, was evaluated in anxious patients prior to oral surgery. This population represents a possible acute screening model for novel anxiolytic agents. Healthy subjects, preselected for a moderate to high degree of dental anxiety based upon Corah’s Dental Anxiety Scale, were enrolled in a three-arm parallel design study and randomly assigned to receive double-blind placebo (N=15), alprazolam 0.25 mg (N=16) or alprazolam 1 mg (N=16). Subjective selfreported anxiety was rated using the State Anxiety Inventory and visual analog scales. Link: ./index.php?lvl=notice_display&id=31045 [artículo] Anticipatory anxiety in moderately to highly-anxious oral surgery patients as a screening model for anxiolytics: evaluation of alprazolam [texto impreso] / Daniel L. Wolf, Autor ; Paul J. Desjardins, Autor ; Peter M. Black, Autor . - 2023 . - pp. 51-57. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 51-57 Palabras clave: Alprazolam, Ansiolíticos, Ansiedad, Presión arterial. Resumen: Alprazolam, a benzodiazepine anxiolytic, was evaluated in anxious patients prior to oral surgery. This population represents a possible acute screening model for novel anxiolytic agents. Healthy subjects, preselected for a moderate to high degree of dental anxiety based upon Corah’s Dental Anxiety Scale, were enrolled in a three-arm parallel design study and randomly assigned to receive double-blind placebo (N=15), alprazolam 0.25 mg (N=16) or alprazolam 1 mg (N=16). Subjective selfreported anxiety was rated using the State Anxiety Inventory and visual analog scales. Link: ./index.php?lvl=notice_display&id=31045

Psychotropic drugs, cardiac arrhythmia, and sudden death / Harry J. Witchel en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 58-77 Título : Psychotropic drugs, cardiac arrhythmia, and sudden death Tipo de documento: texto impreso Autores: Harry J. Witchel, Autor ; Jules C. Hancox, Autor ; David J. Nutt, Autor Fecha de publicación: 2023 Artículo en la página: pp. 58-77 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Arritmias cardiacas, Muerte súbita, Interacción medicamentosa, Síndrome de QT largo. Resumen: A variety of drugs targeted towards the central nervous system are associated with cardiac side effects, some of which are linked with reports of arrhythmia and sudden death. Some psychotropic drugs, particularly tricyclic antidepressants (TCAs) and antipsychotic agents, are correlated with iatrogenic prolongation of the QT interval of the electrocardiogram (ECG). Link: ./index.php?lvl=notice_display&id=31046 [artículo] Psychotropic drugs, cardiac arrhythmia, and sudden death [texto impreso] / Harry J. Witchel, Autor ; Jules C. Hancox, Autor ; David J. Nutt, Autor . - 2023 . - pp. 58-77. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 58-77 Palabras clave: Antipsicóticos, Arritmias cardiacas, Muerte súbita, Interacción medicamentosa, Síndrome de QT largo. Resumen: A variety of drugs targeted towards the central nervous system are associated with cardiac side effects, some of which are linked with reports of arrhythmia and sudden death. Some psychotropic drugs, particularly tricyclic antidepressants (TCAs) and antipsychotic agents, are correlated with iatrogenic prolongation of the QT interval of the electrocardiogram (ECG). Link: ./index.php?lvl=notice_display&id=31046

Dual monoamine modulation for improved treatment of major depressive disorder / Pierre V. Tran en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 78-86 Título : Dual monoamine modulation for improved treatment of major depressive disorder Tipo de documento: texto impreso Autores: Pierre V. Tran, Autor ; Frank P. Bymaster, Autor ; Robert K. McNamara, Autor Fecha de publicación: 2023 Artículo en la página: pp. 78-86 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Inhibidores de la captación adrenérgica, Monoaminas biogénicas, Química cerebral, Trastorno depresivo mayor, Inhibidores de la captación de neurotransmisores. Resumen: The worldwide scope of depressive illness and lack of fully effective pharmacotherapy mandates significant improvements in treatment paradigms. Current antidepressant medications remain limited by poor efficacy, slow onset of action, and untoward side effects. While the introduction of serotoninspecific reuptake inhibitors (SSRIs) offered significant improvements in tolerability, no improvements in efficacy or speed of onset have been made relative to the traditional and poorly tolerated tricyclic antidepressants (TCA). Link: ./index.php?lvl=notice_display&id=31047 [artículo] Dual monoamine modulation for improved treatment of major depressive disorder [texto impreso] / Pierre V. Tran, Autor ; Frank P. Bymaster, Autor ; Robert K. McNamara, Autor . - 2023 . - pp. 78-86. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 1 (Febrero) . - pp. 78-86 Palabras clave: Inhibidores de la captación adrenérgica, Monoaminas biogénicas, Química cerebral, Trastorno depresivo mayor, Inhibidores de la captación de neurotransmisores. Resumen: The worldwide scope of depressive illness and lack of fully effective pharmacotherapy mandates significant improvements in treatment paradigms. Current antidepressant medications remain limited by poor efficacy, slow onset of action, and untoward side effects. While the introduction of serotoninspecific reuptake inhibitors (SSRIs) offered significant improvements in tolerability, no improvements in efficacy or speed of onset have been made relative to the traditional and poorly tolerated tricyclic antidepressants (TCA). Link: ./index.php?lvl=notice_display&id=31047