Artículos

Clozapine use and risk of diabetes mellitus / Philip S. Wang en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 236-243 Título : Clozapine use and risk of diabetes mellitus Tipo de documento: texto impreso Autores: Philip S. Wang, Autor ; Robert J. Glynn, Autor ; David A. Ganz, Autor Fecha de publicación: 2023 Artículo en la página: pp. 236-243 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Clozapina, Diabetes Mellitus. Resumen: Recent reports have raised the concern that clozapine increases the risk for diabetes mellitus. Accurate pharmacoepidemiologic data on whether such a hazard exists and its magnitude are needed to enable clinicians and patients to make proper treatment decisions about clozapine. Link: ./index.php?lvl=notice_display&id=31061 [artículo] Clozapine use and risk of diabetes mellitus [texto impreso] / Philip S. Wang, Autor ; Robert J. Glynn, Autor ; David A. Ganz, Autor . - 2023 . - pp. 236-243. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 236-243 Palabras clave: Antipsicóticos, Clozapina, Diabetes Mellitus. Resumen: Recent reports have raised the concern that clozapine increases the risk for diabetes mellitus. Accurate pharmacoepidemiologic data on whether such a hazard exists and its magnitude are needed to enable clinicians and patients to make proper treatment decisions about clozapine. Link: ./index.php?lvl=notice_display&id=31061

Antipsychotic-induced weight gain and therapeutic response: a differential association / Pál Czobor en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 244-251 Título : Antipsychotic-induced weight gain and therapeutic response: a differential association Tipo de documento: texto impreso Autores: Pál Czobor, Autor ; Jan Volavka, Autor ; Brian Sheitman, Autor Fecha de publicación: 2023 Artículo en la página: pp. 244-251 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Trastornos psicóticos, Esquizofrenia. Resumen: This study investigated the association between antipsychotic-induced weight gain and therapeutic response to haloperidol and three commonly used atypical neuroleptic medications in schizophrenia and schizoaffective disorder. Link: ./index.php?lvl=notice_display&id=31062 [artículo] Antipsychotic-induced weight gain and therapeutic response: a differential association [texto impreso] / Pál Czobor, Autor ; Jan Volavka, Autor ; Brian Sheitman, Autor . - 2023 . - pp. 244-251. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 244-251 Palabras clave: Antipsicóticos, Trastornos psicóticos, Esquizofrenia. Resumen: This study investigated the association between antipsychotic-induced weight gain and therapeutic response to haloperidol and three commonly used atypical neuroleptic medications in schizophrenia and schizoaffective disorder. Link: ./index.php?lvl=notice_display&id=31062

High serum creatinine kinase level: possible risk factor for neuroleptic malignant syndrome / Haggai Hermesh en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 252-256 Título : High serum creatinine kinase level: possible risk factor for neuroleptic malignant syndrome Tipo de documento: texto impreso Autores: Haggai Hermesh, Autor ; Iris Manor, Autor ; Roni Shiloh, Autor Fecha de publicación: 2023 Artículo en la página: pp. 252-256 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Creatina quinasa, Síndrome Neuroléptico Maligno. Resumen: High creatinine kinase (CK) levels and leukocytosis are known to be associated with neuroleptic malignant syndrome (NMS). The authors sought to determine if their presence during non-NMS psychotic episodes is predictive of the later development of NMS. Sixteen psychotic inpatients who met the criteria for NMS were included. Link: ./index.php?lvl=notice_display&id=31063 [artículo] High serum creatinine kinase level: possible risk factor for neuroleptic malignant syndrome [texto impreso] / Haggai Hermesh, Autor ; Iris Manor, Autor ; Roni Shiloh, Autor . - 2023 . - pp. 252-256. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 252-256 Palabras clave: Creatina quinasa, Síndrome Neuroléptico Maligno. Resumen: High creatinine kinase (CK) levels and leukocytosis are known to be associated with neuroleptic malignant syndrome (NMS). The authors sought to determine if their presence during non-NMS psychotic episodes is predictive of the later development of NMS. Sixteen psychotic inpatients who met the criteria for NMS were included. Link: ./index.php?lvl=notice_display&id=31063

Fluoxetine in social phobia: a double-blind, placebo-controlled pilot study / Kenneth Kobak en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 257-262 Título : Fluoxetine in social phobia: a double-blind, placebo-controlled pilot study Tipo de documento: texto impreso Autores: Kenneth Kobak, Autor ; John H. Greist, Autor ; James W. Jefferson, Autor Fecha de publicación: 2023 Artículo en la página: pp. 257-262 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Fluoxetina, Trastornos fóbicos, Inhibidores selectivos de la recaptación de serotonina. Resumen: The objective of the study was to examine the efficacy of fluoxetine in social phobia. Sixty subjects were randomly assigned to 14 weeks of double-blind therapy with either fluoxetine or placebo. Dose was fixed at 20 mg for fluoxetine during the first 8 weeks of double-blind treatment; during the final 6 weeks, the dose could be increased every two weeks by 20 mg to a maximum of 60 mg/day. An intentto-treat analysis was used. Link: ./index.php?lvl=notice_display&id=31064 [artículo] Fluoxetine in social phobia: a double-blind, placebo-controlled pilot study [texto impreso] / Kenneth Kobak, Autor ; John H. Greist, Autor ; James W. Jefferson, Autor . - 2023 . - pp. 257-262. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 257-262 Palabras clave: Fluoxetina, Trastornos fóbicos, Inhibidores selectivos de la recaptación de serotonina. Resumen: The objective of the study was to examine the efficacy of fluoxetine in social phobia. Sixty subjects were randomly assigned to 14 weeks of double-blind therapy with either fluoxetine or placebo. Dose was fixed at 20 mg for fluoxetine during the first 8 weeks of double-blind treatment; during the final 6 weeks, the dose could be increased every two weeks by 20 mg to a maximum of 60 mg/day. An intentto-treat analysis was used. Link: ./index.php?lvl=notice_display&id=31064

Fluoxetine alone in the treatment of first episode anxious-depression: an open clinical trial / Gianfranco Spalletta en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 263-266 Título : Fluoxetine alone in the treatment of first episode anxious-depression: an open clinical trial Tipo de documento: texto impreso Autores: Gianfranco Spalletta, Autor ; Augusto Pasini, Autor ; Carlo Caltagirone, Autor Fecha de publicación: 2023 Artículo en la página: pp. 263-266 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Ansiedad, Trastorno depresivo mayor, Fluoxetina, Inhibidores selectivos de la recaptación de serotonina. Resumen: Many studies have reported the effectiveness of antidepressants in patients with so-called “anxious depression”. This is the first report aimed at studying the beneficial therapeutic effects of fluoxetine alone on anxiety dimension in first episode drug naive patients suffering from DSM-IV major depression (MDD) and double depression (DD). Link: ./index.php?lvl=notice_display&id=31065 [artículo] Fluoxetine alone in the treatment of first episode anxious-depression: an open clinical trial [texto impreso] / Gianfranco Spalletta, Autor ; Augusto Pasini, Autor ; Carlo Caltagirone, Autor . - 2023 . - pp. 263-266. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 263-266 Palabras clave: Ansiedad, Trastorno depresivo mayor, Fluoxetina, Inhibidores selectivos de la recaptación de serotonina. Resumen: Many studies have reported the effectiveness of antidepressants in patients with so-called “anxious depression”. This is the first report aimed at studying the beneficial therapeutic effects of fluoxetine alone on anxiety dimension in first episode drug naive patients suffering from DSM-IV major depression (MDD) and double depression (DD). Link: ./index.php?lvl=notice_display&id=31065

Anxiety and depression symptoms and response to methylphenidate in children with attention-deficit hyperactivity disorder and tic disorder / Kenneth D. Gadow en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 267-274 Título : Anxiety and depression symptoms and response to methylphenidate in children with attention-deficit hyperactivity disorder and tic disorder Tipo de documento: texto impreso Autores: Kenneth D. Gadow, Autor ; Edith E. Nolan, Autor ; Jeffrey Sverd, Autor Fecha de publicación: 2023 Artículo en la página: pp. 267-274 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Ansiedad, Trastorno de Déficit de Atención con Hiperactividad, Estimulantes del Sistema Nervioso Central, Depresión, Trastornos de tics Resumen: This study examined response to methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD) and chronic multiple tic disorder. The primary goal was to determine if children with anxiety or depression symptoms showed a less favorable response to treatment. Subjects were 38 prepubertal children who participated in an 8-week, double-blind, placebo-controlled, methylphenidate crossover evaluation. Link: ./index.php?lvl=notice_display&id=31066 [artículo] Anxiety and depression symptoms and response to methylphenidate in children with attention-deficit hyperactivity disorder and tic disorder [texto impreso] / Kenneth D. Gadow, Autor ; Edith E. Nolan, Autor ; Jeffrey Sverd, Autor . - 2023 . - pp. 267-274. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 267-274 Palabras clave: Ansiedad, Trastorno de Déficit de Atención con Hiperactividad, Estimulantes del Sistema Nervioso Central, Depresión, Trastornos de tics Resumen: This study examined response to methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD) and chronic multiple tic disorder. The primary goal was to determine if children with anxiety or depression symptoms showed a less favorable response to treatment. Subjects were 38 prepubertal children who participated in an 8-week, double-blind, placebo-controlled, methylphenidate crossover evaluation. Link: ./index.php?lvl=notice_display&id=31066

Interactive model of therapeutic response in panic disorder: moclobemide, a case in point / Eberhard H. Uhlenhuth en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 275-284 Título : Interactive model of therapeutic response in panic disorder: moclobemide, a case in point Tipo de documento: texto impreso Autores: Eberhard H. Uhlenhuth, Autor ; Teddy D. Warner, Autor ; William Matuzas, Autor Fecha de publicación: 2023 Artículo en la página: pp. 275-284 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Moclobemida, Trastorno de pánico. Resumen: It was proposed that pre-post regression slopes be used to index treatment response when the effect of baseline scores differed among treatments (interaction between treatment and baseline score). Reanalyses of two studies using imipramine and fluoxetine in panic disorder showed doserelated decreases in pre-post slopes for the frequency of unexpected panic attacks, but not for the frequency of situational panic attacks or measures of agoraphobia. Link: ./index.php?lvl=notice_display&id=31067 [artículo] Interactive model of therapeutic response in panic disorder: moclobemide, a case in point [texto impreso] / Eberhard H. Uhlenhuth, Autor ; Teddy D. Warner, Autor ; William Matuzas, Autor . - 2023 . - pp. 275-284. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 275-284 Palabras clave: Antidepresivos, Moclobemida, Trastorno de pánico. Resumen: It was proposed that pre-post regression slopes be used to index treatment response when the effect of baseline scores differed among treatments (interaction between treatment and baseline score). Reanalyses of two studies using imipramine and fluoxetine in panic disorder showed doserelated decreases in pre-post slopes for the frequency of unexpected panic attacks, but not for the frequency of situational panic attacks or measures of agoraphobia. Link: ./index.php?lvl=notice_display&id=31067

Long-term benzodiazepine use and cognitive decline in the elderly: the epidemiology of vascular aging study / Sabrina Paterniti en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 285-293 Título : Long-term benzodiazepine use and cognitive decline in the elderly: the epidemiology of vascular aging study Tipo de documento: texto impreso Autores: Sabrina Paterniti, Autor ; Carole Dufouil, Autor ; Annick Alpérovitch, Autor Fecha de publicación: 2023 Artículo en la página: pp. 285-293 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Envejecimiento, Ansiedad, Benzodiacepinas, Trastornos cognitivos, Estudios epidemiológicos. Resumen: Several cross-sectional studies have found cognitive impairment in subjects taking benzodiazepines for long periods. However, it is not known whether long-term use of benzodiazepines accelerates cognitive decline in the elderly. The authors addressed this issue in a follow-up study of 1,389 people aged 60 to 70 years recruited from the electoral rolls of the city of Nantes (Epidemiology of Vascular Aging study). Link: ./index.php?lvl=notice_display&id=31068 [artículo] Long-term benzodiazepine use and cognitive decline in the elderly: the epidemiology of vascular aging study [texto impreso] / Sabrina Paterniti, Autor ; Carole Dufouil, Autor ; Annick Alpérovitch, Autor . - 2023 . - pp. 285-293. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 285-293 Palabras clave: Envejecimiento, Ansiedad, Benzodiacepinas, Trastornos cognitivos, Estudios epidemiológicos. Resumen: Several cross-sectional studies have found cognitive impairment in subjects taking benzodiazepines for long periods. However, it is not known whether long-term use of benzodiazepines accelerates cognitive decline in the elderly. The authors addressed this issue in a follow-up study of 1,389 people aged 60 to 70 years recruited from the electoral rolls of the city of Nantes (Epidemiology of Vascular Aging study). Link: ./index.php?lvl=notice_display&id=31068

Duration of imipramine therapy and relapse in panic disorder with agoraphobia / Matig Mavissakalian en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 294-299 Título : Duration of imipramine therapy and relapse in panic disorder with agoraphobia Tipo de documento: texto impreso Autores: Matig Mavissakalian, Autor ; James Perel, Autor Fecha de publicación: 2023 Artículo en la página: pp. 294-299 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Agorafobia, Agentes antidepresivos tricíclicos, Imipramina, Trastorno de pánico. Resumen: It has been suggested that maintenance treatment of patients who have remitted panic disorder with agoraphobia beyond the six months of acute phase imipramine treatment may decrease the risk of relapse. This study further explores the relationship between relapse and duration of imipramine treatment in this population. Link: ./index.php?lvl=notice_display&id=31069 [artículo] Duration of imipramine therapy and relapse in panic disorder with agoraphobia [texto impreso] / Matig Mavissakalian, Autor ; James Perel, Autor . - 2023 . - pp. 294-299. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 294-299 Palabras clave: Agorafobia, Agentes antidepresivos tricíclicos, Imipramina, Trastorno de pánico. Resumen: It has been suggested that maintenance treatment of patients who have remitted panic disorder with agoraphobia beyond the six months of acute phase imipramine treatment may decrease the risk of relapse. This study further explores the relationship between relapse and duration of imipramine treatment in this population. Link: ./index.php?lvl=notice_display&id=31069

Antipanic drug modulation of 35% co2 hyperreactivity and short-term treatment outcome / Giampaolo Perna en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 300-308 Título : Antipanic drug modulation of 35% co2 hyperreactivity and short-term treatment outcome Tipo de documento: texto impreso Autores: Giampaolo Perna, Autor ; Angelo Bertani, Autor ; Daniela Caldirola, Autor Fecha de publicación: 2023 Artículo en la página: pp. 300-308 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Agorafobia, Hiperreactividad Bronquial, Trastorno de pánico. Resumen: Carbon dioxide (CO2) inhalation induces acute anxiety and panic attacks in patients with Panic Disorder (PD). Anti-panic drugs decrease CO2 reactivity after the first days of treatment; however, the clinical meaning of this finding has not yet been established. This study investigated the effects of treatment with tricyclic antidepressants and selective serotonin re-uptake inhibitors (SSRIs) on CO2 reactivity and compared the relationships between 35% CO2 hyperreactivity modulation and short-term clinical outcome. Link: ./index.php?lvl=notice_display&id=31070 [artículo] Antipanic drug modulation of 35% co2 hyperreactivity and short-term treatment outcome [texto impreso] / Giampaolo Perna, Autor ; Angelo Bertani, Autor ; Daniela Caldirola, Autor . - 2023 . - pp. 300-308. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 300-308 Palabras clave: Agorafobia, Hiperreactividad Bronquial, Trastorno de pánico. Resumen: Carbon dioxide (CO2) inhalation induces acute anxiety and panic attacks in patients with Panic Disorder (PD). Anti-panic drugs decrease CO2 reactivity after the first days of treatment; however, the clinical meaning of this finding has not yet been established. This study investigated the effects of treatment with tricyclic antidepressants and selective serotonin re-uptake inhibitors (SSRIs) on CO2 reactivity and compared the relationships between 35% CO2 hyperreactivity modulation and short-term clinical outcome. Link: ./index.php?lvl=notice_display&id=31070

Multivariate meta-analysis of controlled drug studies for obsessive-compulsive disorder / Deborah L. Ackerman en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 309-317 Título : Multivariate meta-analysis of controlled drug studies for obsessive-compulsive disorder Tipo de documento: texto impreso Autores: Deborah L. Ackerman, Autor ; Sander Greenland, Autor Fecha de publicación: 2023 Artículo en la página: pp. 309-317 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Clomipramina, Trastorno obsesivo-compulsivo, Ensayos controlados aleatorios, Inhibidores selectivos de la recaptación de serotonina. Resumen: Meta-analytic reviews of placebo-controlled studies for obsessive-compulsive disorder have found that clomipramine is more effective than drugs with more selective actions on serotonin reuptake, whereas in most direct comparisons, clomipramine’s superiority has been less obvious. Link: ./index.php?lvl=notice_display&id=31071 [artículo] Multivariate meta-analysis of controlled drug studies for obsessive-compulsive disorder [texto impreso] / Deborah L. Ackerman, Autor ; Sander Greenland, Autor . - 2023 . - pp. 309-317. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 309-317 Palabras clave: Clomipramina, Trastorno obsesivo-compulsivo, Ensayos controlados aleatorios, Inhibidores selectivos de la recaptación de serotonina. Resumen: Meta-analytic reviews of placebo-controlled studies for obsessive-compulsive disorder have found that clomipramine is more effective than drugs with more selective actions on serotonin reuptake, whereas in most direct comparisons, clomipramine’s superiority has been less obvious. Link: ./index.php?lvl=notice_display&id=31071

Effects of interrater reliability of psychopathologic assessment on power and sample size calculations in clinical trials / Matthias J. Müller en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 318-325 Título : Effects of interrater reliability of psychopathologic assessment on power and sample size calculations in clinical trials Tipo de documento: texto impreso Autores: Matthias J. Müller, Autor ; Armin Szegedi, Autor Fecha de publicación: 2023 Artículo en la página: pp. 318-325 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Ensayos clínicos, Psicopatología Resumen: Although rater training is increasingly used to improve the quality of the investigated outcome parameters, the reliability of assessments is not perfect. Thus, empirical reliability estimates should be used instead of theoretically assumed perfect reliability. Implications of the reliability of psychiatric assessments for sample size and power calculations in clinical trials are presented. Link: ./index.php?lvl=notice_display&id=31072 [artículo] Effects of interrater reliability of psychopathologic assessment on power and sample size calculations in clinical trials [texto impreso] / Matthias J. Müller, Autor ; Armin Szegedi, Autor . - 2023 . - pp. 318-325. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 3 (Junio) . - pp. 318-325 Palabras clave: Ensayos clínicos, Psicopatología Resumen: Although rater training is increasingly used to improve the quality of the investigated outcome parameters, the reliability of assessments is not perfect. Thus, empirical reliability estimates should be used instead of theoretically assumed perfect reliability. Implications of the reliability of psychiatric assessments for sample size and power calculations in clinical trials are presented. Link: ./index.php?lvl=notice_display&id=31072