Artículos

The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients / Aya Yokono en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 549-555 Título : The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients Tipo de documento: texto impreso Autores: Aya Yokono, Autor ; Sachiyo Morita, Autor ; Toshiyuki Someya, Autor Fecha de publicación: 2023 Artículo en la página: pp. 549-555 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos tricíclicos, Clomipramina, Citocromo P-450 CYP2C19, Sistema enzimático citocromo P-450, Trastorno Depresivo, Oxigenasas de función mixta, Mutación genética. Resumen: In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2 weeks to obtain steady-state concentrations. Link: ./index.php?lvl=notice_display&id=31099 [artículo] The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients [texto impreso] / Aya Yokono, Autor ; Sachiyo Morita, Autor ; Toshiyuki Someya, Autor . - 2023 . - pp. 549-555. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 549-555 Palabras clave: Antidepresivos tricíclicos, Clomipramina, Citocromo P-450 CYP2C19, Sistema enzimático citocromo P-450, Trastorno Depresivo, Oxigenasas de función mixta, Mutación genética. Resumen: In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2 weeks to obtain steady-state concentrations. Link: ./index.php?lvl=notice_display&id=31099

Ssris and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram / Marcel D. Waldinger en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 556-560 Título : Ssris and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram Tipo de documento: texto impreso Autores: Marcel D. Waldinger, Autor ; Aeilko H. Zwinderman, Autor ; Berend Olivier, Autor Fecha de publicación: 2023 Artículo en la página: pp. 556-560 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Citalopram, Eyaculación - fisiología, Paroxetina, Inhibidores selectivos de la recaptación de serotonina. Resumen: Selective serotonin reuptake inhibitors (SSRIs) are known to induce delayed orgasm and ejaculation. However, different SSRIs may differentially delay ejaculation. A double-blind, fixed-dose study in healthy men with lifelong rapid ejaculation was performed to evaluate potential differences between clinically relevant doses of two selective serotonin reuptake inhibitors, paroxetine and citalopram, in their effects on ejaculation. Link: ./index.php?lvl=notice_display&id=31100 [artículo] Ssris and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram [texto impreso] / Marcel D. Waldinger, Autor ; Aeilko H. Zwinderman, Autor ; Berend Olivier, Autor . - 2023 . - pp. 556-560. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 556-560 Palabras clave: Citalopram, Eyaculación - fisiología, Paroxetina, Inhibidores selectivos de la recaptación de serotonina. Resumen: Selective serotonin reuptake inhibitors (SSRIs) are known to induce delayed orgasm and ejaculation. However, different SSRIs may differentially delay ejaculation. A double-blind, fixed-dose study in healthy men with lifelong rapid ejaculation was performed to evaluate potential differences between clinically relevant doses of two selective serotonin reuptake inhibitors, paroxetine and citalopram, in their effects on ejaculation. Link: ./index.php?lvl=notice_display&id=31100

The double-blind variable placebo lead-in period: results from two antidepressant clinical trials / Douglas E. Faries en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 561-568 Título : The double-blind variable placebo lead-in period: results from two antidepressant clinical trials Tipo de documento: texto impreso Autores: Douglas E. Faries, Autor ; John H. Heiligenstein, Autor ; Gary D. Tollefson, Autor Fecha de publicación: 2023 Artículo en la página: pp. 561-568 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Ensayos clínicos, Trastorno depresivo mayor, Ensayos controlados aleatorios Resumen: The 1-week single-blind placebo lead-in has long been a standard in double-blind psychopharmacology clinical trials. Although a lead-in period is often necessary (e.g., to receive laboratory results before randomization), some authors have demonstrated that the standard single-blind placebo lead-in’s performance was similar to having a lead-in in which placebo was not administered. Link: ./index.php?lvl=notice_display&id=31101 [artículo] The double-blind variable placebo lead-in period: results from two antidepressant clinical trials [texto impreso] / Douglas E. Faries, Autor ; John H. Heiligenstein, Autor ; Gary D. Tollefson, Autor . - 2023 . - pp. 561-568. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 561-568 Palabras clave: Antidepresivos, Ensayos clínicos, Trastorno depresivo mayor, Ensayos controlados aleatorios Resumen: The 1-week single-blind placebo lead-in has long been a standard in double-blind psychopharmacology clinical trials. Although a lead-in period is often necessary (e.g., to receive laboratory results before randomization), some authors have demonstrated that the standard single-blind placebo lead-in’s performance was similar to having a lead-in in which placebo was not administered. Link: ./index.php?lvl=notice_display&id=31101

Individual changes in clozapine levels after smoking cessation: results and a predictive model / Jonathan M. Meyer en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 569-574 Título : Individual changes in clozapine levels after smoking cessation: results and a predictive model Tipo de documento: texto impreso Autores: Jonathan M. Meyer, Autor Fecha de publicación: 2023 Artículo en la página: pp. 569-574 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos tricíclicos, Clozapina, Modelos psicológicos, Fumar, Tabaquismo - psicología, Dejar de fumar. Resumen: Published reports document 20–40% lower mean serum clozapine concentrations in smokers compared with nonsmokers due to enzyme induction. Despite the increase in nonsmoking psychiatric facilities in the United States, previous studies have not tracked individual changes in serum clozapine levels after smoking cessation. Link: ./index.php?lvl=notice_display&id=31102 [artículo] Individual changes in clozapine levels after smoking cessation: results and a predictive model [texto impreso] / Jonathan M. Meyer, Autor . - 2023 . - pp. 569-574. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 569-574 Palabras clave: Antidepresivos tricíclicos, Clozapina, Modelos psicológicos, Fumar, Tabaquismo - psicología, Dejar de fumar. Resumen: Published reports document 20–40% lower mean serum clozapine concentrations in smokers compared with nonsmokers due to enzyme induction. Despite the increase in nonsmoking psychiatric facilities in the United States, previous studies have not tracked individual changes in serum clozapine levels after smoking cessation. Link: ./index.php?lvl=notice_display&id=31102

The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia / Floortje E. Scheepers en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 575-582 Título : The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia Tipo de documento: texto impreso Autores: Floortje E. Scheepers, Autor ; Christine C. Gispen De Wied, Autor ; René S. Kahn, Autor Fecha de publicación: 2023 Artículo en la página: pp. 575-582 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Hormona adrenocorticotrópica, Benzodiazepinas, Hormonas - metabolismo, Piperazinas, Prolactina, Receptor de serotonina 5-HT2C, Esquizofrenia. Resumen: In addition to dopamine, serotonin (5-hydroxytryptamine, 5-HT) has been reported to play an important role in schizophrenia. Besides blocking dopamine, atypical antipsychotics also block 5-HT receptors. The clinical efficacy of the atypical antipsychotic clozapine is associated with the 5-HT antagonistic action of the drug and a high serotonergic tone before treatment. Link: ./index.php?lvl=notice_display&id=31103 [artículo] The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia [texto impreso] / Floortje E. Scheepers, Autor ; Christine C. Gispen De Wied, Autor ; René S. Kahn, Autor . - 2023 . - pp. 575-582. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 575-582 Palabras clave: Hormona adrenocorticotrópica, Benzodiazepinas, Hormonas - metabolismo, Piperazinas, Prolactina, Receptor de serotonina 5-HT2C, Esquizofrenia. Resumen: In addition to dopamine, serotonin (5-hydroxytryptamine, 5-HT) has been reported to play an important role in schizophrenia. Besides blocking dopamine, atypical antipsychotics also block 5-HT receptors. The clinical efficacy of the atypical antipsychotic clozapine is associated with the 5-HT antagonistic action of the drug and a high serotonergic tone before treatment. Link: ./index.php?lvl=notice_display&id=31103

The efficacy and safety of risperidone for the treatment of geriatric psychosis / Jen Ping Hwang en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 583-587 Título : The efficacy and safety of risperidone for the treatment of geriatric psychosis Tipo de documento: texto impreso Autores: Jen Ping Hwang, Autor ; Cheng Hung Yang, Autor ; Hsieh-Chiao Yu, Autor Fecha de publicación: 2023 Artículo en la página: pp. 583-587 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Envejecimiento, Antipsicóticos, Breve escala de calificación psiquiátrica, Trastornos psicóticos, Risperidona. Resumen: Risperidone is an atypical antipsychotic drug which has been suggested to be beneficial for the treatment of elderly patients with psychotic symptoms. In this study, we assessed the short-term efficacy and the safety of risperidone in geropsychiatric inpatients with psychotic symptoms. The sample population included 110 elderly inpatients with psychotic disorders. Link: ./index.php?lvl=notice_display&id=31104 [artículo] The efficacy and safety of risperidone for the treatment of geriatric psychosis [texto impreso] / Jen Ping Hwang, Autor ; Cheng Hung Yang, Autor ; Hsieh-Chiao Yu, Autor . - 2023 . - pp. 583-587. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 583-587 Palabras clave: Envejecimiento, Antipsicóticos, Breve escala de calificación psiquiátrica, Trastornos psicóticos, Risperidona. Resumen: Risperidone is an atypical antipsychotic drug which has been suggested to be beneficial for the treatment of elderly patients with psychotic symptoms. In this study, we assessed the short-term efficacy and the safety of risperidone in geropsychiatric inpatients with psychotic symptoms. The sample population included 110 elderly inpatients with psychotic disorders. Link: ./index.php?lvl=notice_display&id=31104

Pharmacoepidemiologic investigation of a clonazepam-carbamazepine interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients / Eiji Yukawa en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 588-593 Título : Pharmacoepidemiologic investigation of a clonazepam-carbamazepine interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients Tipo de documento: texto impreso Autores: Eiji Yukawa, Autor ; Toshiharu Nonaka, Autor ; Miho Yukawa, Autor Fecha de publicación: 2023 Artículo en la página: pp. 588-593 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Anticonvulsivos, Carbamazepina, Clonazepam, Interacciones farmacológicas, Japón - epidemiología, Farmacoepidemiología Resumen: Nonlinear mixed effects modeling was used to estimate the effects of clonazepam-carbamazepine interaction on clearance values using 359 serum levels gathered from 183 pediatric and adult epileptic patients (age range, 0.3–26.8 years) during their clinical routine care. Patients received the administration of clonazepam and/or carbamazepine. Link: ./index.php?lvl=notice_display&id=31105 [artículo] Pharmacoepidemiologic investigation of a clonazepam-carbamazepine interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients [texto impreso] / Eiji Yukawa, Autor ; Toshiharu Nonaka, Autor ; Miho Yukawa, Autor . - 2023 . - pp. 588-593. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 588-593 Palabras clave: Anticonvulsivos, Carbamazepina, Clonazepam, Interacciones farmacológicas, Japón - epidemiología, Farmacoepidemiología Resumen: Nonlinear mixed effects modeling was used to estimate the effects of clonazepam-carbamazepine interaction on clearance values using 359 serum levels gathered from 183 pediatric and adult epileptic patients (age range, 0.3–26.8 years) during their clinical routine care. Patients received the administration of clonazepam and/or carbamazepine. Link: ./index.php?lvl=notice_display&id=31105