Artículos

Long-term benzodiazepine therapy does not result in brain abnormalities / Usoa E. Busto en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 2-6 Título : Long-term benzodiazepine therapy does not result in brain abnormalities Tipo de documento: texto impreso Autores: Usoa E. Busto, Autor ; Karen E. Bremner, Autor ; Kathryn Knight, Autor Fecha de publicación: 2023 Artículo en la página: pp. 2-6 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Ansiolíticos, Atrofia, Benzodiazepinas, Cerebro - diagnóstico por imágenes, Efectos cerebrales del medicamento. Resumen: Studies on the association between long-term benzodiazepine use and brain abnormalities have yielded conflicting results. The computed tomographic (CT) scans of 20 long-term users of benzodiazepine (65% men; mean age ± SD [range], 42 ± 12.1 years [23-59]; mean daily benzodiazepine dose [diazepam equivalents], 19.5 ± 16.2 mg [2.5-70]; mean cumulative benzodiazepine exposure, 55.2 g [1.8-198]) were compared with 36 age- (±3 years) and sex-matched controls. Link: ./index.php?lvl=notice_display&id=31224 [artículo] Long-term benzodiazepine therapy does not result in brain abnormalities [texto impreso] / Usoa E. Busto, Autor ; Karen E. Bremner, Autor ; Kathryn Knight, Autor . - 2023 . - pp. 2-6. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 2-6 Palabras clave: Ansiolíticos, Atrofia, Benzodiazepinas, Cerebro - diagnóstico por imágenes, Efectos cerebrales del medicamento. Resumen: Studies on the association between long-term benzodiazepine use and brain abnormalities have yielded conflicting results. The computed tomographic (CT) scans of 20 long-term users of benzodiazepine (65% men; mean age ± SD [range], 42 ± 12.1 years [23-59]; mean daily benzodiazepine dose [diazepam equivalents], 19.5 ± 16.2 mg [2.5-70]; mean cumulative benzodiazepine exposure, 55.2 g [1.8-198]) were compared with 36 age- (±3 years) and sex-matched controls. Link: ./index.php?lvl=notice_display&id=31224

Comparison of the frequency of behavioral disinhibition on alprazolam, clonazepam, or no benzodiazepine in hospitalized psychiatric patients / Anthony J. Rothschild en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 7-11 Título : Comparison of the frequency of behavioral disinhibition on alprazolam, clonazepam, or no benzodiazepine in hospitalized psychiatric patients Tipo de documento: texto impreso Autores: Anthony J. Rothschild, Autor ; Judith A. Shindul Rothschild, Autor ; Adele C. Viguera, Autor Fecha de publicación: 2023 Artículo en la página: pp. 7-11 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Alprazolam, Ansiolíticos, Síntomas conductuales, Clonazepam, Hospitalización, Trastornos mentales. Resumen: Several case reports have suggested that treatment with the benzodiazepine alprazolam can result in behavioral disinhibition. To address this question, the authors reviewed the medical records (blinded to all pharmacologic treatments the patients received) of 323 psychiatric inpatients treated with alprazolam (108 patients), clonazepam (111 patients), or no benzodiazepine (104 patients) between January 1989 and June 1990. Link: ./index.php?lvl=notice_display&id=31225 [artículo] Comparison of the frequency of behavioral disinhibition on alprazolam, clonazepam, or no benzodiazepine in hospitalized psychiatric patients [texto impreso] / Anthony J. Rothschild, Autor ; Judith A. Shindul Rothschild, Autor ; Adele C. Viguera, Autor . - 2023 . - pp. 7-11. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 7-11 Palabras clave: Alprazolam, Ansiolíticos, Síntomas conductuales, Clonazepam, Hospitalización, Trastornos mentales. Resumen: Several case reports have suggested that treatment with the benzodiazepine alprazolam can result in behavioral disinhibition. To address this question, the authors reviewed the medical records (blinded to all pharmacologic treatments the patients received) of 323 psychiatric inpatients treated with alprazolam (108 patients), clonazepam (111 patients), or no benzodiazepine (104 patients) between January 1989 and June 1990. Link: ./index.php?lvl=notice_display&id=31225

A double-blind, placebo-controlled trial of abecarnil and diazepam in the treatment of patients with generalized anxiety disorder / Karl Rickels en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 12-18 Título : A double-blind, placebo-controlled trial of abecarnil and diazepam in the treatment of patients with generalized anxiety disorder Tipo de documento: texto impreso Autores: Karl Rickels, Autor ; Nicholas DeMartinis, Autor ; Bernd Aufdembrinke, Autor Fecha de publicación: 2023 Artículo en la página: pp. 12-18 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Ansiolíticos, Trastornos de ansiedad, Diazepam. Resumen: In a multicenter, double-blind trial, 310 patients who had received a diagnosis of generalized anxiety disorder were treated for 6 weeks with either abecarnil, diazepam, or placebo at mean daily doses of 12 mg of abecarnil or 22 mg of diazepam administered three times daily. Patients who were improved at 6 weeks could volunteer to continue double-blind treatment for a total of 24 weeks. Link: ./index.php?lvl=notice_display&id=31226 [artículo] A double-blind, placebo-controlled trial of abecarnil and diazepam in the treatment of patients with generalized anxiety disorder [texto impreso] / Karl Rickels, Autor ; Nicholas DeMartinis, Autor ; Bernd Aufdembrinke, Autor . - 2023 . - pp. 12-18. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 12-18 Palabras clave: Ansiolíticos, Trastornos de ansiedad, Diazepam. Resumen: In a multicenter, double-blind trial, 310 patients who had received a diagnosis of generalized anxiety disorder were treated for 6 weeks with either abecarnil, diazepam, or placebo at mean daily doses of 12 mg of abecarnil or 22 mg of diazepam administered three times daily. Patients who were improved at 6 weeks could volunteer to continue double-blind treatment for a total of 24 weeks. Link: ./index.php?lvl=notice_display&id=31226

Clonazepam and sertraline: absence of drug interaction in a multiple-dose study / Peter L. Bonate en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 19-27 Título : Clonazepam and sertraline: absence of drug interaction in a multiple-dose study Tipo de documento: texto impreso Autores: Peter L. Bonate, Autor ; Patricia D. Kroboth, Autor ; Randall B. Smith, Autor Fecha de publicación: 2023 Artículo en la página: pp. 19-27 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Clonazepam, Interaccion medicamentosa, Moduladores GABA, Rendimiento psicomotor, Inhibidores selectivos de la recaptación de serotonina, Sertralina. Resumen: Thirteen subjects (seven men, six women) completed a placebo-controlled, randomized, double-blind, crossover study to determine whether an interaction occurs between clonazepam and sertraline. Ten days of once-daily doses of either clonazepam 1 mg and placebo (CZ + PL) or clonazepam 1 mg and sertraline 100 mg (CZ + SR) were administered; there was an 11-day washout period. Link: ./index.php?lvl=notice_display&id=31227 [artículo] Clonazepam and sertraline: absence of drug interaction in a multiple-dose study [texto impreso] / Peter L. Bonate, Autor ; Patricia D. Kroboth, Autor ; Randall B. Smith, Autor . - 2023 . - pp. 19-27. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 19-27 Palabras clave: Clonazepam, Interaccion medicamentosa, Moduladores GABA, Rendimiento psicomotor, Inhibidores selectivos de la recaptación de serotonina, Sertralina. Resumen: Thirteen subjects (seven men, six women) completed a placebo-controlled, randomized, double-blind, crossover study to determine whether an interaction occurs between clonazepam and sertraline. Ten days of once-daily doses of either clonazepam 1 mg and placebo (CZ + PL) or clonazepam 1 mg and sertraline 100 mg (CZ + SR) were administered; there was an 11-day washout period. Link: ./index.php?lvl=notice_display&id=31227

Double-blind, placebo-controlled study with reboxetine in inpatients with severe major depressive disorder / Marcio Versiani en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 28-34 Título : Double-blind, placebo-controlled study with reboxetine in inpatients with severe major depressive disorder Tipo de documento: texto impreso Autores: Marcio Versiani, Autor ; Mohammed Amin, Autor ; Guy Chouinard, Autor Fecha de publicación: 2023 Artículo en la página: pp. 28-34 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Trastorno depresivo mayor, Morfolinas. Resumen: The efficacy and tolerability of reboxetine, a unique selective noradrenaline reuptake inhibitor, were compared with those of placebo in a 6-week, randomized, double-blind study of hospitalized patients with a DSM-III-R diagnosis of major depressive disorder. Fifty-two patients (25 in the placebo group, 27 in the reboxetine group) were included in the efficacy analysis. Link: ./index.php?lvl=notice_display&id=31228 [artículo] Double-blind, placebo-controlled study with reboxetine in inpatients with severe major depressive disorder [texto impreso] / Marcio Versiani, Autor ; Mohammed Amin, Autor ; Guy Chouinard, Autor . - 2023 . - pp. 28-34. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 28-34 Palabras clave: Antidepresivos, Trastorno depresivo mayor, Morfolinas. Resumen: The efficacy and tolerability of reboxetine, a unique selective noradrenaline reuptake inhibitor, were compared with those of placebo in a 6-week, randomized, double-blind study of hospitalized patients with a DSM-III-R diagnosis of major depressive disorder. Fifty-two patients (25 in the placebo group, 27 in the reboxetine group) were included in the efficacy analysis. Link: ./index.php?lvl=notice_display&id=31228

Fluvoxamine-clozapine drug interaction: inhibition in vitro of five cytochrome p450 isoforms involved in clozapine metabolism / Ole V. Olesen en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 35-42 Título : Fluvoxamine-clozapine drug interaction: inhibition in vitro of five cytochrome p450 isoforms involved in clozapine metabolism Tipo de documento: texto impreso Autores: Ole V. Olesen, Autor ; Kristian Linnet, Autor Fecha de publicación: 2023 Artículo en la página: pp. 35-42 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Clozapina, Sistema enzimático citocromo P-450, Interacción medicamentosa, Fluvoxamina, Isoenzimas, Inhibidores selectivos de la recaptación de serotonina. Resumen: Administration of fluvoxamine to patients receiving clozapine therapy may increase the steady-state serum concentrations of clozapine by a factor of 5 to 10. The authors undertook in vitro studies to disclose the mechanism behind this clinically important interaction. In a human liver microsome preparation, fluvoxamine showed a concentration-dependent inhibition of clozapine N-demethylation. Link: ./index.php?lvl=notice_display&id=31229 [artículo] Fluvoxamine-clozapine drug interaction: inhibition in vitro of five cytochrome p450 isoforms involved in clozapine metabolism [texto impreso] / Ole V. Olesen, Autor ; Kristian Linnet, Autor . - 2023 . - pp. 35-42. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 35-42 Palabras clave: Clozapina, Sistema enzimático citocromo P-450, Interacción medicamentosa, Fluvoxamina, Isoenzimas, Inhibidores selectivos de la recaptación de serotonina. Resumen: Administration of fluvoxamine to patients receiving clozapine therapy may increase the steady-state serum concentrations of clozapine by a factor of 5 to 10. The authors undertook in vitro studies to disclose the mechanism behind this clinically important interaction. In a human liver microsome preparation, fluvoxamine showed a concentration-dependent inhibition of clozapine N-demethylation. Link: ./index.php?lvl=notice_display&id=31229

Cytochrome p450 2d6 and treatment of codeine dependence / Myroslava K. Romach en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 43-45 Título : Cytochrome p450 2d6 and treatment of codeine dependence Tipo de documento: texto impreso Autores: Myroslava K. Romach, Autor ; S. Victoria Otton, Autor ; Gail Somer, Autor Fecha de publicación: 2023 Artículo en la página: pp. 43-45 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Analgésicos, Opioides, Codeína, Citocromo P-450 CYP2D6, Fluoxetina, Trastornos relacionados con opioides. Resumen: Oral opioid analgesics such as codeine are used extensively worldwide and are frequently misused. Codeine is a substrate of CYP2D6, a genetically polymorphic P450 enzyme, and is metabolized to the more potent drug morphine. CYP2D6 activity can be inhibited by fluoxetine, and the inhibition of morphine formation may help individuals reduce their use of codeine. Link: ./index.php?lvl=notice_display&id=31230 [artículo] Cytochrome p450 2d6 and treatment of codeine dependence [texto impreso] / Myroslava K. Romach, Autor ; S. Victoria Otton, Autor ; Gail Somer, Autor . - 2023 . - pp. 43-45. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 43-45 Palabras clave: Analgésicos, Opioides, Codeína, Citocromo P-450 CYP2D6, Fluoxetina, Trastornos relacionados con opioides. Resumen: Oral opioid analgesics such as codeine are used extensively worldwide and are frequently misused. Codeine is a substrate of CYP2D6, a genetically polymorphic P450 enzyme, and is metabolized to the more potent drug morphine. CYP2D6 activity can be inhibited by fluoxetine, and the inhibition of morphine formation may help individuals reduce their use of codeine. Link: ./index.php?lvl=notice_display&id=31230

Carbamazepine-nefazodone interaction in healthy subjects / Cécile Laroudie en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 46-53 Título : Carbamazepine-nefazodone interaction in healthy subjects Tipo de documento: texto impreso Autores: Cécile Laroudie, Autor ; Daniel E. Salazar, Autor ; Jean Philippe Cosson, Autor Fecha de publicación: 2023 Artículo en la página: pp. 46-53 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Antimaníacos, Carbamazepina, Citocromo P-450 CYP2D6, Triazoles. Resumen: The pharmacokinetic interaction between nefazodone and carbamazepine was investigated in 12 healthy male volunteers. Subjects received nefazodone 200 mg twice daily for 5 days, and blood sample collection was performed on day 5 for 0- to 48-hour pharmacokinetic analysis. A 4-day washout phase then followed from days 6 to 9. Carbamazepine 200 mg was administered once daily from days 10 to 12, and then 200 mg was given twice daily from days 13 to 44. A 0- to 48-hour pharmacokinetic analysis was performed on day 38. Link: ./index.php?lvl=notice_display&id=31231 [artículo] Carbamazepine-nefazodone interaction in healthy subjects [texto impreso] / Cécile Laroudie, Autor ; Daniel E. Salazar, Autor ; Jean Philippe Cosson, Autor . - 2023 . - pp. 46-53. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 46-53 Palabras clave: Antidepresivos, Antimaníacos, Carbamazepina, Citocromo P-450 CYP2D6, Triazoles. Resumen: The pharmacokinetic interaction between nefazodone and carbamazepine was investigated in 12 healthy male volunteers. Subjects received nefazodone 200 mg twice daily for 5 days, and blood sample collection was performed on day 5 for 0- to 48-hour pharmacokinetic analysis. A 4-day washout phase then followed from days 6 to 9. Carbamazepine 200 mg was administered once daily from days 10 to 12, and then 200 mg was given twice daily from days 13 to 44. A 0- to 48-hour pharmacokinetic analysis was performed on day 38. Link: ./index.php?lvl=notice_display&id=31231

Efficacy of quetiapine in parkinson's patients with psychosis / Steven David Targum en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 54-60 Título : Efficacy of quetiapine in parkinson's patients with psychosis Tipo de documento: texto impreso Autores: Steven David Targum, Autor ; Jacob L. Abbott, Autor Fecha de publicación: 2023 Artículo en la página: pp. 54-60 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Dibenzotiacepinas, Enfermedad de Parkinson, Psicosis inducidas por sustancias. Resumen: Eleven patients with Parkinson's disease (PD) and acute psychosis received flexible doses of quetiapine between 25 and 300 mg/day based on clinical response and tolerance. Ten patients were receiving dopaminergic agents at baseline. Serial efficacy ratings (Brief Psychiatric Rating Scale, Clinical Global Impressions Scale), neuromuscular symptom assessments (Abnormal Involuntary Movement Scale, Simpson-Angus Scale, Unified Parkinson's Disease Rating Scale [UPDRS]), and adverse events monitoring were performed for up to 52 weeks. Link: ./index.php?lvl=notice_display&id=31232 [artículo] Efficacy of quetiapine in parkinson's patients with psychosis [texto impreso] / Steven David Targum, Autor ; Jacob L. Abbott, Autor . - 2023 . - pp. 54-60. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 54-60 Palabras clave: Antipsicóticos, Dibenzotiacepinas, Enfermedad de Parkinson, Psicosis inducidas por sustancias. Resumen: Eleven patients with Parkinson's disease (PD) and acute psychosis received flexible doses of quetiapine between 25 and 300 mg/day based on clinical response and tolerance. Ten patients were receiving dopaminergic agents at baseline. Serial efficacy ratings (Brief Psychiatric Rating Scale, Clinical Global Impressions Scale), neuromuscular symptom assessments (Abnormal Involuntary Movement Scale, Simpson-Angus Scale, Unified Parkinson's Disease Rating Scale [UPDRS]), and adverse events monitoring were performed for up to 52 weeks. Link: ./index.php?lvl=notice_display&id=31232

Laboratory measures of methylphenidate effects in cocaine-dependent patients receiving treatment / John D. Roache en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 61-68 Título : Laboratory measures of methylphenidate effects in cocaine-dependent patients receiving treatment Tipo de documento: texto impreso Autores: John D. Roache, Autor ; John Grabowski, Autor ; Joy M. Schmitz, Autor Fecha de publicación: 2023 Artículo en la página: pp. 61-68 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Afecto, Estimulantes del sistema nervioso central, Trastornos relacionados con la cocaína, Frecuencia cardíaca, Metilfenidato. Resumen: Two experiments examined the effects of methylphenidate in male and female patients enrolled in an outpatient treatment program for primary cocaine dependence. The first study was a component of a double-blind efficacy trial wherein 57 patients were first tested in a human laboratory for their initial responsiveness to medication. Patients were randomly assigned to receive either placebo or methylphenidate treatment and received their first dose in the human laboratory environment before continuing in outpatient treatment. Link: ./index.php?lvl=notice_display&id=31233 [artículo] Laboratory measures of methylphenidate effects in cocaine-dependent patients receiving treatment [texto impreso] / John D. Roache, Autor ; John Grabowski, Autor ; Joy M. Schmitz, Autor . - 2023 . - pp. 61-68. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 61-68 Palabras clave: Afecto, Estimulantes del sistema nervioso central, Trastornos relacionados con la cocaína, Frecuencia cardíaca, Metilfenidato. Resumen: Two experiments examined the effects of methylphenidate in male and female patients enrolled in an outpatient treatment program for primary cocaine dependence. The first study was a component of a double-blind efficacy trial wherein 57 patients were first tested in a human laboratory for their initial responsiveness to medication. Patients were randomly assigned to receive either placebo or methylphenidate treatment and received their first dose in the human laboratory environment before continuing in outpatient treatment. Link: ./index.php?lvl=notice_display&id=31233

Naltrexone-induced nausea in patients treated for alcohol dependence: clinical predictors and evidence for opioid-mediated effects / Stephanie S. O'Malley en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 69-76 Título : Naltrexone-induced nausea in patients treated for alcohol dependence: clinical predictors and evidence for opioid-mediated effects Tipo de documento: texto impreso Autores: Stephanie S. O'Malley, Autor ; Suchitra Krishnan Sarin, Autor ; Conor Farren, Autor Fecha de publicación: 2023 Artículo en la página: pp. 69-76 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Alcoholismo, Farmacoterapia, Modelos Logísticos, Naltrexona, Antagonistas narcóticos, Náuseas, Aspectos sexuales, Templanza. Resumen: Naltrexone, an opiate antagonist, is well tolerated by most alcoholic patients; however, a subset reports significant nausea that can limit the effectiveness of this therapy. The goal of this study was to identify risk factors for naltrexone-precipitated nausea to assist in the development of management strategies to maximize the overall effectiveness of naltrexone. Link: ./index.php?lvl=notice_display&id=31234 [artículo] Naltrexone-induced nausea in patients treated for alcohol dependence: clinical predictors and evidence for opioid-mediated effects [texto impreso] / Stephanie S. O'Malley, Autor ; Suchitra Krishnan Sarin, Autor ; Conor Farren, Autor . - 2023 . - pp. 69-76. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 69-76 Palabras clave: Alcoholismo, Farmacoterapia, Modelos Logísticos, Naltrexona, Antagonistas narcóticos, Náuseas, Aspectos sexuales, Templanza. Resumen: Naltrexone, an opiate antagonist, is well tolerated by most alcoholic patients; however, a subset reports significant nausea that can limit the effectiveness of this therapy. The goal of this study was to identify risk factors for naltrexone-precipitated nausea to assist in the development of management strategies to maximize the overall effectiveness of naltrexone. Link: ./index.php?lvl=notice_display&id=31234

Comparison of central and peripheral pharmacologic effects of biperiden and trihexyphenidyl in human volunteers / Sally K. Guthrie en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 77-83 Título : Comparison of central and peripheral pharmacologic effects of biperiden and trihexyphenidyl in human volunteers Tipo de documento: texto impreso Autores: Sally K. Guthrie, Autor ; Laura Manzey, Autor ; Doneka Scott, Autor Fecha de publicación: 2023 Artículo en la página: pp. 77-83 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Biperideno, Hemodinámica, Recuerdo mental, Antagonistas muscarínicos, Rendimiento psicomotor, Salivación. Resumen: In this double-blind, randomized study, indices of central (memory, sedation) and peripheral (salivation, ratio of R-R interval on electrocardiogram) muscarinic function were evaluated in 14 healthy volunteers who received trihexyphenidyl, biperiden, and placebo. Additionally, serum drug levels were obtained 2 hours after oral administration. All subjects participated in three study sessions. During each session, subjects received two doses of biperiden (4 mg), trihexyphenidyl (5 mg), or placebo, and four series of tests were administered. Link: ./index.php?lvl=notice_display&id=31235 [artículo] Comparison of central and peripheral pharmacologic effects of biperiden and trihexyphenidyl in human volunteers [texto impreso] / Sally K. Guthrie, Autor ; Laura Manzey, Autor ; Doneka Scott, Autor . - 2023 . - pp. 77-83. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 77-83 Palabras clave: Biperideno, Hemodinámica, Recuerdo mental, Antagonistas muscarínicos, Rendimiento psicomotor, Salivación. Resumen: In this double-blind, randomized study, indices of central (memory, sedation) and peripheral (salivation, ratio of R-R interval on electrocardiogram) muscarinic function were evaluated in 14 healthy volunteers who received trihexyphenidyl, biperiden, and placebo. Additionally, serum drug levels were obtained 2 hours after oral administration. All subjects participated in three study sessions. During each session, subjects received two doses of biperiden (4 mg), trihexyphenidyl (5 mg), or placebo, and four series of tests were administered. Link: ./index.php?lvl=notice_display&id=31235

Efficacy of kava extract for treating anxiety: systematic review and meta-analysis / Max H. Pittler en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 84-89 Título : Efficacy of kava extract for treating anxiety: systematic review and meta-analysis Tipo de documento: texto impreso Autores: Max H. Pittler, Autor ; Edzard Ernst, Autor Fecha de publicación: 2023 Artículo en la página: pp. 84-89 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Ansiedad, Kava - uso terapéutico, Fitoterapia, Extractos de Plantas, Plantas Medicinales. Resumen: Synthetic anxiolytic drugs are effective for treating anxiety, but they are burdened with adverse effects. Constraints on resources and time often render therapies such as psychologic interventions impracticable. Thus, an effective oral medication with few adverse effects would be a welcome addition to the therapeutic repertoire. Link: ./index.php?lvl=notice_display&id=31236 [artículo] Efficacy of kava extract for treating anxiety: systematic review and meta-analysis [texto impreso] / Max H. Pittler, Autor ; Edzard Ernst, Autor . - 2023 . - pp. 84-89. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 84-89 Palabras clave: Ansiedad, Kava - uso terapéutico, Fitoterapia, Extractos de Plantas, Plantas Medicinales. Resumen: Synthetic anxiolytic drugs are effective for treating anxiety, but they are burdened with adverse effects. Constraints on resources and time often render therapies such as psychologic interventions impracticable. Thus, an effective oral medication with few adverse effects would be a welcome addition to the therapeutic repertoire. Link: ./index.php?lvl=notice_display&id=31236