Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulbectomised rat model of depression / Valentina Gigliucci en European Neuropsychopharmacology, Año 2014 - Vol. 24 - No.8 (Agosto)

Público ISBD [artículo]  inEuropean Neuropsychopharmacology > Año 2014 - Vol. 24 - No.8 (Agosto) . - pp. 1349-1361 Título : Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulbectomised rat model of depression Tipo de documento: texto impreso Autores: Valentina Gigliucci, Autor ; Shane Gormley, Autor ; Sinead M. Gibney, Autor Fecha de publicación: 2021 Artículo en la página: pp. 1349-1361 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Óxido nítrico sintasa, Antidepresivo, Depresión, Rata bulbectomizada olfativa, Campo abierto, Imagen de resonancia magnética Resumen: Nitric oxide synthase (NOS) inhibitors possess antidepressant-like properties in preclinical tests and in the current investigation the brain penetrant NOS inhibitor Nω-nitro-l-arginine (l-NA) and the preferential inhibitor of neuronal NOS (nNOS) 1-(2-trifluoromethylphenyl) imidazole (TRIM) were assessed in the olfactory bulbectomised (OB) rat, a well-established animal model of depression. Link: ./index.php?lvl=notice_display&id=26908 [artículo] Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulbectomised rat model of depression [texto impreso] / Valentina Gigliucci, Autor ; Shane Gormley, Autor ; Sinead M. Gibney, Autor . - 2021 . - pp. 1349-1361. Idioma : Inglés (eng) Idioma original : Inglés (eng) in European Neuropsychopharmacology > Año 2014 - Vol. 24 - No.8 (Agosto) . - pp. 1349-1361 Palabras clave: Óxido nítrico sintasa, Antidepresivo, Depresión, Rata bulbectomizada olfativa, Campo abierto, Imagen de resonancia magnética Resumen: Nitric oxide synthase (NOS) inhibitors possess antidepressant-like properties in preclinical tests and in the current investigation the brain penetrant NOS inhibitor Nω-nitro-l-arginine (l-NA) and the preferential inhibitor of neuronal NOS (nNOS) 1-(2-trifluoromethylphenyl) imidazole (TRIM) were assessed in the olfactory bulbectomised (OB) rat, a well-established animal model of depression. Link: ./index.php?lvl=notice_display&id=26908

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