In vitro inhibition of pimozide n-dealkylation by selective serotonin reuptake inhibitors and azithromycin / Zeruesenay Desta en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 2 (Abril) . - pp. 162-168 Título : In vitro inhibition of pimozide n-dealkylation by selective serotonin reuptake inhibitors and azithromycin Tipo de documento: texto impreso Autores: Zeruesenay Desta, Autor ; Nadia Soukhova, Autor ; David A. Flockhart, Autor Fecha de publicación: 2023 Artículo en la página: pp. 162-168 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Azitromicina, Inhibidores de la enzima citocromo P-450, Técnicas In Vitro, Microsomas, Oxidorreductasas. Resumen: Pimozide is often coprescribed with serotonin reuptake inhibitor (SSRI) antidepressants to treat depression in patients with Tourette’s syndrome. In human liver microsomes (HLMs), the inhibition of the primary route of pimozide metabolism, N-dealkylation to 1,3-dihydro-1-(4–piperidinyl)-2H-benzimidazol-2-one (DHPBI), by four SSRIs (fluoxetine, sertraline, paroxetine, and fluvoxamine) and azithromycin was tested. Link: ./index.php?lvl=notice_display&id=31081 [artículo] In vitro inhibition of pimozide n-dealkylation by selective serotonin reuptake inhibitors and azithromycin [texto impreso] / Zeruesenay Desta, Autor ; Nadia Soukhova, Autor ; David A. Flockhart, Autor . - 2023 . - pp. 162-168. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 2 (Abril) . - pp. 162-168 Palabras clave: Azitromicina, Inhibidores de la enzima citocromo P-450, Técnicas In Vitro, Microsomas, Oxidorreductasas. Resumen: Pimozide is often coprescribed with serotonin reuptake inhibitor (SSRI) antidepressants to treat depression in patients with Tourette’s syndrome. In human liver microsomes (HLMs), the inhibition of the primary route of pimozide metabolism, N-dealkylation to 1,3-dihydro-1-(4–piperidinyl)-2H-benzimidazol-2-one (DHPBI), by four SSRIs (fluoxetine, sertraline, paroxetine, and fluvoxamine) and azithromycin was tested. Link: ./index.php?lvl=notice_display&id=31081

Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with tourette syndrome / David A. Flockhart en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 3 (Junio) . - pp. 317-324 Título : Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with tourette syndrome Tipo de documento: texto impreso Autores: David A. Flockhart, Autor ; Milou Daniel Drici, Autor ; Thomas Kerbusch, Autor Fecha de publicación: 2023 Artículo en la página: pp. 317-324 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Claritromicina, Muerte súbita, Electrocardiografía, Microsomas, Pimozida, Síndrome de Tourette. Resumen: The authors report in detail the case of a 27-year-old man who experienced sudden cardiac death 2 days after coprescription of the neuroleptic pimozide and the macrolide antibiotic clarithromycin after the documentation of a prolonged QT interval. To determine the prevalence of this interaction, the authors referred to the Spontaneous Reporting System of the Food and Drug Administration and identified one similar case in which clarithromycin was coprescribed with pimozide and sudden cardiac death occurred shortly thereafter. Link: ./index.php?lvl=notice_display&id=31189 [artículo] Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with tourette syndrome [texto impreso] / David A. Flockhart, Autor ; Milou Daniel Drici, Autor ; Thomas Kerbusch, Autor . - 2023 . - pp. 317-324. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 3 (Junio) . - pp. 317-324 Palabras clave: Antipsicóticos, Claritromicina, Muerte súbita, Electrocardiografía, Microsomas, Pimozida, Síndrome de Tourette. Resumen: The authors report in detail the case of a 27-year-old man who experienced sudden cardiac death 2 days after coprescription of the neuroleptic pimozide and the macrolide antibiotic clarithromycin after the documentation of a prolonged QT interval. To determine the prevalence of this interaction, the authors referred to the Spontaneous Reporting System of the Food and Drug Administration and identified one similar case in which clarithromycin was coprescribed with pimozide and sudden cardiac death occurred shortly thereafter. Link: ./index.php?lvl=notice_display&id=31189

Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with Tourette syndrome / David A. Flockhart en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 3 (Junio) . - pp. 317-324 Título : Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with Tourette syndrome Tipo de documento: texto impreso Autores: David A. Flockhart, Autor ; Milou Daniel Drici, Autor ; Thomas Kerbusch, Autor Fecha de publicación: 2023 Artículo en la página: pp. 317-324 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Claritromicina, Muerte súbita, Electrocardiografía, Microsomas, Pimozida, Síndrome de Tourette. Resumen: The authors report in detail the case of a 27-year-old man who experienced sudden cardiac death 2 days after coprescription of the neuroleptic pimozide and the macrolide antibiotic clarithromycin after the documentation of a prolonged QT interval. To determine the prevalence of this interaction, the authors referred to the Spontaneous Reporting System of the Food and Drug Administration and identified one similar case in which clarithromycin was coprescribed with pimozide and sudden cardiac death occurred shortly thereafter. Link: ./index.php?lvl=notice_display&id=31198 [artículo] Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with Tourette syndrome [texto impreso] / David A. Flockhart, Autor ; Milou Daniel Drici, Autor ; Thomas Kerbusch, Autor . - 2023 . - pp. 317-324. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 3 (Junio) . - pp. 317-324 Palabras clave: Antipsicóticos, Claritromicina, Muerte súbita, Electrocardiografía, Microsomas, Pimozida, Síndrome de Tourette. Resumen: The authors report in detail the case of a 27-year-old man who experienced sudden cardiac death 2 days after coprescription of the neuroleptic pimozide and the macrolide antibiotic clarithromycin after the documentation of a prolonged QT interval. To determine the prevalence of this interaction, the authors referred to the Spontaneous Reporting System of the Food and Drug Administration and identified one similar case in which clarithromycin was coprescribed with pimozide and sudden cardiac death occurred shortly thereafter. Link: ./index.php?lvl=notice_display&id=31198

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