Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from st. John’s wort (hypericum perforatum) / Andreas Johne en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 2 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 2 (Febrero) . - pp. 46-54 Título : Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from st. John’s wort (hypericum perforatum) Tipo de documento: texto impreso Autores: Andreas Johne, Autor ; Jürgen Schmider, Autor ; Jürgen Brockmöller, Autor Fecha de publicación: 2023 Artículo en la página: pp. 46-54 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Amitriptilina, Trastorno depresivo, Interacción medicamentosa, Nortriptilina, Fitoterapia, Extractos de Plantas. Resumen: Extracts of St. John’s wort (Hypericum perforatum) became increasingly popular as easily available remedies for mild to moderate depression. Comedication with hypericum extract was recently shown to drastically reduce plasma concentration of ciclosporin, digoxin, and indinavir. We investigated the possible interaction of hypericum extract LI160 with amitriptyline. Both antidepressants have a high probability of concomitant use. Link: ./index.php?lvl=notice_display&id=31093 [artículo] Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from st. John’s wort (hypericum perforatum) [texto impreso] / Andreas Johne, Autor ; Jürgen Schmider, Autor ; Jürgen Brockmöller, Autor . - 2023 . - pp. 46-54. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 2 (Febrero) . - pp. 46-54 Palabras clave: Amitriptilina, Trastorno depresivo, Interacción medicamentosa, Nortriptilina, Fitoterapia, Extractos de Plantas. Resumen: Extracts of St. John’s wort (Hypericum perforatum) became increasingly popular as easily available remedies for mild to moderate depression. Comedication with hypericum extract was recently shown to drastically reduce plasma concentration of ciclosporin, digoxin, and indinavir. We investigated the possible interaction of hypericum extract LI160 with amitriptyline. Both antidepressants have a high probability of concomitant use. Link: ./index.php?lvl=notice_display&id=31093

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