Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline / Sachiyo Morita en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 141-149 Título : Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline Tipo de documento: texto impreso Autores: Sachiyo Morita, Autor ; Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor Fecha de publicación: 2023 Artículo en la página: pp. 141-149 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos de adaptación, Trastorno bipolar, Trastorno depresivo mayor, Etnia - genética, Nortriptilina. Resumen: The authors investigated the impact of the CYP2D6 genotype on steady-state concentrations of nortriptyline (NT) and its metabolites, trans-10-hydroxynortriptyline (EHNT) and cis-10-hydroxynortriptyline in a Japanese population of psychiatric patients. Forty-one patients (20 men and 21 women) were orally administered nortriptyline hydrochloride. Link: ./index.php?lvl=notice_display&id=31208 [artículo] Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline [texto impreso] / Sachiyo Morita, Autor ; Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor . - 2023 . - pp. 141-149. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 141-149 Palabras clave: Trastornos de adaptación, Trastorno bipolar, Trastorno depresivo mayor, Etnia - genética, Nortriptilina. Resumen: The authors investigated the impact of the CYP2D6 genotype on steady-state concentrations of nortriptyline (NT) and its metabolites, trans-10-hydroxynortriptyline (EHNT) and cis-10-hydroxynortriptyline in a Japanese population of psychiatric patients. Forty-one patients (20 men and 21 women) were orally administered nortriptyline hydrochloride. Link: ./index.php?lvl=notice_display&id=31208

The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients / Aya Yokono en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 549-555 Título : The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients Tipo de documento: texto impreso Autores: Aya Yokono, Autor ; Sachiyo Morita, Autor ; Toshiyuki Someya, Autor Fecha de publicación: 2023 Artículo en la página: pp. 549-555 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos tricíclicos, Clomipramina, Citocromo P-450 CYP2C19, Sistema enzimático citocromo P-450, Trastorno Depresivo, Oxigenasas de función mixta, Mutación genética. Resumen: In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2 weeks to obtain steady-state concentrations. Link: ./index.php?lvl=notice_display&id=31099 [artículo] The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients [texto impreso] / Aya Yokono, Autor ; Sachiyo Morita, Autor ; Toshiyuki Someya, Autor . - 2023 . - pp. 549-555. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 549-555 Palabras clave: Antidepresivos tricíclicos, Clomipramina, Citocromo P-450 CYP2C19, Sistema enzimático citocromo P-450, Trastorno Depresivo, Oxigenasas de función mixta, Mutación genética. Resumen: In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2 weeks to obtain steady-state concentrations. Link: ./index.php?lvl=notice_display&id=31099

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