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[artículo]
| Título : |
Pharmacologic profile of perphenazine's metabolites |
| Tipo de documento: |
texto impreso |
| Autores: |
Robert A. Sweet, Autor ; Bruce G. Pollock, Autor ; Benoit H. Mulsant, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 181-187 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Antipsicóticos, Efectos cerebrales, Demencia, Antagonistas de la dopamina, Perfenazina. |
| Resumen: |
The authors have previously reported that in elderly patients treated with low doses of perphenazine, few extrapyramidal symptoms (EPS) developed in those who were not poor CYP2D6 metabolizers. The authors hypothesized that this atypical side effect profile is due to perphenazine's principal metabolite, n-dealkylperphenazine (DAPZ), which is usually present in vivo at concentrations 1.5 to 2 times that of the parent drug. |
| Link: |
./index.php?lvl=notice_display&id=31213 |
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 181-187
|
Pharmacologic profile of perphenazine's metabolites en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)
